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Monoamine oxidase A and B Gene polymorphisms and negative and positive symptoms in schizophrenia

dc.creatorCamarena, Beatriz
dc.creatorFresan, Ana
dc.creatorAguilar, Alejandro
dc.creatorEscamilla, Raul
dc.creatorSaracco, Ricardo
dc.creatorPalacios, jorge
dc.creatorTovilla, Alfonso
dc.creatorNicolini1, Humberto
dc.date.accessioned2017-06-29T04:00:21Z
dc.date.available2017-06-29T04:00:21Z
dc.date.issued2012es_ES
dc.identifier2836es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4685
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658801/es_ES
dc.language.isoenges_ES
dc.publisherCairo, Egypt : Hindawi Pub. Corp.es_ES
dc.relation19, 1-5 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleMonoamine oxidase A and B Gene polymorphisms and negative and positive symptoms in schizophreniaes_ES
dc.typeartículoes_ES
dc.contributor.affiliationPosgrado de Ciencias Gen´omicas, Universidad Aut´onoma de la Ciudad de M´exico, 03100 M´exico, DF, Mexicoes_ES
dc.contributor.emailnicolini humberto@yahoo.comes_ES
dc.relation.jnabreviadoISRN PSYCHIATRYes_ES
dc.relation.journalISRN Psychiatryes_ES
dc.identifier.placeEgiptoes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2090-7966es_ES
dc.identifier.doi10.5402/2012/852949es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaGiven that schizophrenia is a heterogeneous disorder, the analysis of clinical characteristics could help to identify homogeneous phenotypes that may be of relevance in genetic studies. Linkage and association studies have suggested that a locus predisposing to schizophrenia may reside within Xp11. We analyzed uVNTR and rs1137070, polymorphisms from MAOA and rs1799836 of MAOB genes to perform single SNP case-control association study in a sample of 344 schizophrenia patients and 124 control subjects. Single polymorphism analysis of uVNTR, rs1137070 and rs1799836 SNPs did not show statistical differences between cases and controls.Multivariate ANOVA analysis of clinical characteristics showed statistical differences between MAOB/rs1799836 and affective flattening scores (F = 4.852, P = 0.009), and significant association between MAOA/uVNTR and affective flattening in female schizophrenia patients (F = 4.236, P = 0.016) after Bonferroni’s correction. Our preliminary findings could suggest that severity of affective flattening may be associated by modifier variants of MAOA and MAOB genes in female Mexican patients with schizophrenia. However, further large-scale studies using quantitative symptom-based phenotypes and several candidate variants should be analyzed to obtain a final conclusion.es_ES


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