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Microtubule organization and L-type voltage-activated calcium current in olfactory neuronal cells obtained from patients with schizophrenia and bipolar disorder 

dc.creatorSolis-Chagoyan, H.
dc.creatorCalixto, E.
dc.creatorFigueroa, A.
dc.creatorMontano, L. M.
dc.creatorBerlanga, C.
dc.creatorRodriguez-Verdugo, M.S.
dc.creatorRomo, F.
dc.creatorJimenez, M.
dc.creatorZepeda Gurrola, C.
dc.creatorRiquelme, A.
dc.creatorBenitez-King, G.
dc.date.accessioned2017-06-29T03:59:45Z
dc.date.available2017-06-29T03:59:45Z
dc.date.issued2013es_ES
dc.identifier2831es_ES
dc.identifier.issn0920-9964es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4680
dc.identifier.urihttps://doi.org/10.1016/j.schres.2012.11.035es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherElsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlandses_ES
dc.relation143 (2-3) 384-389 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshBiomarkers/metabolismes_ES
dc.subject.meshBipolar Disorder/metabolismes_ES
dc.subject.meshBipolar Disorder/pathologyes_ES
dc.subject.meshCalcium/metabolismes_ES
dc.subject.meshCalcium Channels, L-Type/metabolismes_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshHumanses_ES
dc.subject.meshMicrotubules/metabolismes_ES
dc.subject.meshMicrotubules/pathologyes_ES
dc.subject.meshNeurons/metabolismes_ES
dc.subject.meshNeurons/pathologyes_ES
dc.subject.meshNifedipinees_ES
dc.subject.meshPatch-Clamp Techniqueses_ES
dc.subject.meshSchizophrenia/metabolismes_ES
dc.subject.meshSchizophrenia/pathologyes_ES
dc.titleMicrotubule organization and L-type voltage-activated calcium current in olfactory neuronal cells obtained from patients with schizophrenia and bipolar disorder es_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Dept Neurofarmacología, SIC, Calzada Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailbekin@imp.edu.mx es_ES
dc.relation.jnabreviadoSCHIZOPHR RESes_ES
dc.relation.journalSchizophrenia Researches_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1573-2509es_ES
dc.identifier.doi10.1016/j.schres.2012.11.035 es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaOlfactory neuroepithelial cells in culture have been proposed as a model to study the physiopathology of psychiatric disorders and biomarker characterization for diagnosis. In patients with schizophrenia (SZ) and bipolar disorder (BD) diminished microtubule-associated proteins expression occurs, which might lead to aberrant microtubular organization and which in turn may affect Ca2+ voltage-activated currents. The aim of this work was to characterize of microtubule organization as well as of the L-type Ca2+ current in neuronal precursors obtained from nasal exfoliates of patients with SZ and BD. Microtubule organization was studied by immunofluorescence with a specific anti-III beta-tubulin antibody and by quantification of globular and assembled tubulin by Western blot. L-type current recording was performed by whole-cell patch-clamp technique and nifedipine superfusion. The results showed differential altered microtubular organization in neuronal precursors of SZ and BD. Short microtubules were observed in BD neurons, while extensive, unstained subcellular areas and disorganized microtubules were evident in SZ neuronal precursors. Patients with BD showed a decrease in amounts of tubulin in total homogenates and 40% decrease in the globular fraction. However, L-type current in BD was similar to that in healthy subjects (HS). In contrast, this current in SZ was 50% lower. These reduction in L-type current in SZ together with differential microtubule alterations are potential biomarkers that may differentiates SZ and BD. (C) 2012 Elsevier B. V. All rights reserved.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koSchizophreniaes_ES
dc.subject.koBiomarkerses_ES
dc.subject.koMicrotubulees_ES
dc.subject.koCalcium currentes_ES
dc.subject.koBipolar disorderes_ES


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