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Melatonin synergizes with citalopram to induce antidepressant- like behavior and to promote hippocampal neurogenesis in adult mice

dc.creatorRamirez-Rodriguez, Gerardo
dc.creatorMaritza Vega-Rivera, Nelly
dc.creatorOikawa-Sala, Julian
dc.creatorGomez-Sanchez, Ariadna
dc.creatorOrtiz-Lopez, Leonardo
dc.creatorEstrada-Camarena, Erika
dc.date.accessioned2017-06-29T03:58:22Z
dc.date.available2017-06-29T03:58:22Z
dc.date.issued2014es_ES
dc.identifier2818es_ES
dc.identifier.issn0742-3098es_ES
dc.identifier.urihttp://dx.doi.org/10.1111/jpi.12136es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4667
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherNew York : Liss, c1984 : Oxford : Wileyes_ES
dc.relation56 (4) 450-461 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleMelatonin synergizes with citalopram to induce antidepressant- like behavior and to promote hippocampal neurogenesis in adult micees_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDivision of Clinical Research, Laboratory of Neurogenesis, National Institute of Psychiatry "Ramon de la Fuente Muniz", Mexico, D.F., Mexicoes_ES
dc.contributor.emailgbernabe@imp.edu.mxes_ES
dc.relation.jnabreviadoJ PINEAL RESes_ES
dc.relation.journalJournal of Pineal Researches_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1600-079Xes_ES
dc.identifier.doi10.1111/jpi.12136. Epub 2014 Apr 11es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaAdult hippocampal neurogenesis is affected in some neuropsychiatric disorders such as depression. Numerous evidence indicates that plasma levels of melatonin are decreased in depressed patients. Also, melatonin exerts positive effects on the hippocampal neurogenic process and on depressive-like behavior. In addition, antidepressants revert alterations of hippocampal neurogenesis present in models of depression following a similar time course to the improvement of behavior. In this study, we analyzed the effects of both, citalopram, a widely used antidepressant, and melatonin in the Porsolt forced swim test. In addition, we investigated the potential antidepressant role of the combination of melatonin and citalopram (MLTCITAL), its type of pharmacological interaction on depressive behavior, and its effect on hippocampal neurogenesis. Here, we found decreased immobility behavior in mice treated with melatonin (<14-33%) and citalopram (<17-30%). Additionally, the MLTCITAL combination also decreased immobility (<22-35%) in comparison with control mice, reflecting an antidepressant-like effect after 14 days of treatment. Moreover, MLTCITAL decreased plasma corticosterone levels (≤13%) and increased cell proliferation (>29%), survival (>39%), and the absolute number of -associated new neurons (>53%) in the dentate gyrus of the hippocampus. These results indicate that the MLTCITAL combination exerts synergism to induce an antidepressant-like action that could be related to the modulation of adult hippocampal neurogenesis. This outcome opens the opportunity of using melatonin to promote behavioral benefits and hippocampal neurogenesis in depression and also supports the use of the MLTCITAL combination as an alternative to treat depression.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koAdult neurogenesises_ES
dc.subject.koAntidepressantses_ES
dc.subject.koCitaloprames_ES
dc.subject.koHippocampuses_ES
dc.subject.koMelatonines_ES
dc.subject.koNeurogenesises_ES


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