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Melatonin modulates microfilament phenotypes in epithelial cells: implications for adhesion and inhibition of cancer cell migration

dc.creatorBenítez-King, Gloria
dc.creatorSoto-Vega, Elena
dc.creatorRamírez-Rodriguez, Gerardo
dc.date.accessioned2017-06-29T03:58:12Z
dc.date.available2017-06-29T03:58:12Z
dc.date.issued2009es_ES
dc.identifier2816es_ES
dc.identifier.issn0213-3911es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4665
dc.identifier.urihttp://doi.org/10.14670/HH-24.789es_ES
dc.language.isoenges_ES
dc.publisherMurcia. Histology and Histopathologyes_ES
dc.relation24 (6) 789-799 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshActin Cytoskeleton-Metabolismes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCell Adhesion-Physiologyes_ES
dc.subject.meshCell Movement-Physiologyes_ES
dc.subject.meshCytoskeleton-Metabolismes_ES
dc.subject.meshEpithelial Cells-Metabolismes_ES
dc.subject.meshHumanses_ES
dc.subject.meshMelatonin-Metabolismes_ES
dc.subject.meshNeoplasm Invasivenesses_ES
dc.subject.meshNeoplasms-Metabolismes_ES
dc.subject.meshPhenotypees_ES
dc.titleMelatonin modulates microfilament phenotypes in epithelial cells: implications for adhesion and inhibition of cancer cell migrationes_ES
dc.typeartículoes_ES
dc.contributor.affiliationNeuropharmacology Department, Division of Clinical Investigations, National Institute of Psychiatry Ramón de la Fuente Muñizes_ES
dc.contributor.emailbekin@imp.edu.mxes_ES
dc.relation.jnabreviadoHISTOL HISTOPATHOLes_ES
dc.relation.journalHistology and Histopathologyes_ES
dc.identifier.placeEspañaes_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1699-5848es_ES
dc.description.abstractotrodiomaCell migration and adhesion are cytoskeleton- dependent functions that play a key role in epithelial physiology. Specialized epithelial cells in water transport have specific microfilament rearrangements that make these cells adopt a polyhedral shape, forming a sealed monolayer which functions as permeability barrier. Also, specific polarized microfilament phenotypes are formed at the front and the rear of migratory epithelial cells. In pathological processes such as cancer, increased migration occurs in invasive cells driven by the formation of polarized and differential microfilament phenotypes. Melatonin, the main product secreted by the pineal gland during dark phase of the photoperiod, acts as a cytoskeletal modulator in normal and cancer cells. In this paper we will summarize evidence supporting that melatonin acts as a microfilament modulator in epithelial MDCK cells, and we will describe its effects on cytoskeleton organization involved in the mechanism by which melatonin synchronizes water transport. In addition, we will review recent data that indicate that melatonin is able to switch microfilament phenotypes in MCF-7 human mammary cancer cells, from invasive migratory cells to dormant microfilament phenotypes that occur in non- migratory cells. Moreover, we will discuss the implications of the cytoskeleton as therapeutic target for cancer cells.es_ES
dc.subject.koMelatonines_ES
dc.subject.koCytoskeletales_ES
dc.subject.koCalmodulines_ES
dc.subject.koProtein kinase Ces_ES
dc.subject.koCanceres_ES


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