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Melatonin increases dendritogenesis in the hilus of hippocampal organotypic cultures

dc.creatorDominguez-Alonso, Aline
dc.creatorRamirez-Rodriguez, Gerardo
dc.creatorBenitez-King, Gloria
dc.date.accessioned2017-06-29T03:58:02Z
dc.date.available2017-06-29T03:58:02Z
dc.date.issued2012es_ES
dc.identifier2814es_ES
dc.identifier.issn0742-3098es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4663
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2011.00957.xes_ES
dc.language.isoenges_ES
dc.publisherNew York : Liss, c1984 : Oxford : Wileyes_ES
dc.relation52 (4) 427-436 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalysis of Variancees_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshDendrites-Drug effectses_ES
dc.subject.meshDendrites-Metabolismes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshHippocampus-Cytologyes_ES
dc.subject.meshHippocampus-Drug effectses_ES
dc.subject.meshHippocampus-Metabolismes_ES
dc.subject.meshImmunohistochemistryes_ES
dc.subject.meshMalees_ES
dc.subject.meshMelatonin-Pharmacologyes_ES
dc.subject.meshNeurogenesis-Drug effectses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshSynapses-Drug effectses_ES
dc.subject.meshSynapses-Metabolismes_ES
dc.subject.meshSynaptophysines_ES
dc.subject.meshVesicular Transport Proteins-Metabolismes_ES
dc.titleMelatonin increases dendritogenesis in the hilus of hippocampal organotypic cultureses_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Neurofarmacologia, Subdireccion de Investigaciones Clinicas, Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz, Mexico, D.F.es_ES
dc.contributor.emailbekin@imp.edu.mxes_ES
dc.relation.jnabreviadoJ PINEAL RESes_ES
dc.relation.journalJournal of Pineal Researches_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1600-079Xes_ES
dc.identifier.doi10.1111/j.1600-079X.2011.00957.xes_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaNeuropsychiatric disorders are characterized by hippocampus decreased volume and loss of dendrite arborizations in the subiculum and prefrontal cortex. These structural changes are associated with diminished memory performance. Hilar neurons of the hippocampus integrate spatial memory and are lost in dementia. They receive information from dentate gyrus neurons through dendrites, while they send axonal tracts to the CA3 region. Dendrites are complex structures of neurons that receive chemical information from presynaptic and postsynaptic terminals. Melatonin, the main product of the pineal gland, has neuroprotective actions through its free radical-scavenging properties and decreases neuronal apoptosis. Recently, we found that melatonin increases dendrite maturation and complexity in new neurons formed in the dentate gyrus of mice. In addition, in N1E-115 cultured cells, the indole stimulates early stages of neurite formation, a process that is known to antecede dendrite formation and maturation. Thus, in this study, we explored whether melatonin stimulates dendrite formation and complexity in the adult rat hippocampus in organotypic slice cultures, which is a model that preserves the hippocampal circuitry and their tridimensional organizations of connectivity. The effects of melatonin were studied in nonpathological conditions and in the absence of harmful agents. The results showed that the indole at nocturnal concentrations reached in the cerebrospinal fluid stimulates dendritogenesis at formation, growth, and maturation stages. Also, data showed that dendrites formed became competent to form presynaptic specializations. Evidence strongly suggests that melatonin may be useful in the treatment of neuropsychiatric diseases to repair the loss of dendrites and re-establish lost synaptic connections.es_ES
dc.subject.koDendritogenesises_ES
dc.subject.koHippocampuses_ES
dc.subject.koMelatonines_ES
dc.subject.koSynapseses_ES


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