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Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency

dc.creatorAlvarez-Salas, Elena
dc.creatorAlcántara-Alonso, Viridiana
dc.creatorMatamoros-Trejo, Gilberto
dc.creatorVargas, Miguel Angel
dc.creatorMorales-Mulia, Marcela
dc.creatorDe Gortari, Patricia
dc.date.accessioned2017-06-29T03:57:50Z
dc.date.available2017-06-29T03:57:50Z
dc.date.issued2015es_ES
dc.identifier2812es_ES
dc.identifier.issn0736-5748es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijdevneu.2015.08.001es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4661
dc.language.isoenges_ES
dc.publisherOxford : Elsevier Sciencees_ES
dc.relation46, 115-124 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleMediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiencyes_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartment of Neurosciences Research, National Institute of Psychiatry Ramon de la Fuente Muñiz (INPRFM), Calzada México-Xochimilco 101, C.P. 14370, Mexico City, Mexicoes_ES
dc.contributor.emailgortari@imp.edu.mxes_ES
dc.relation.jnabreviadoINT J DEV NEUROSCIes_ES
dc.relation.journalInternational Journal of Developmental Neurosciencees_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2015es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-474Xes_ES
dc.identifier.doi10.1016/j.ijdevneu.2015.08.001es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaThyrotropin-releasing hormone (TRH) synthesized in hypothalamic paraventricular nucleus directs hypothalamus-pituitary-thyroid (HPT) axis function, regulating thyrotropin release from adenohypophysis and thyroid hormones serum concentration. Pyroglutamyl aminopeptidase II (PPII), a Zn-dependent metallopeptidase located in adenohypophysis and medial-basal-hypothalamus degrades TRH released from the median eminence and participates in HPT axis function by regulating TRH-induced thyrotropin release from adenohypophysis. It is unknown whether dietary Zn deficiency down-regulates PPII. Our aim was to compare adenohypohyseal and medial-basal-hypothalamic PPII activity and expression of adult rats fed a Zn-deficient diet (2 ppm) throughout their lifespan (DD), prenatally (DC) or after weaning (CD) vs. that of animals fed a control diet (20 ppm:CC). Female rats consumed a Zn-deficient or control diet from two weeks before gestation and up to the end of lactation. We analyzed adenohypophyseal and medial-basal-hypothalamic PPII activity of dams and male offspring when adults; its relation to median eminence TRH, serum thyrotropin, leptin and thyroid hormones concentration. Offspring ate the same diet as their dams (CC, DD) or were switched from dietary regime after weaning (CD, DC) and until 2.5 months of age. DD males showed decreased adenohypophyseal and medial-basal-hypothalamic PPII activity, along with high thyrotropin serum concentration. Post-weaning Zn-deficiency (CD) decreased PPII activity only in adenohypophysis and increased thyrotropin circulating levels. Zn-replenishment (DC) normalized PPII activity in both regions and serum thyrotropin concentration. Adenohypophyseal PPII activity decreased and prolactin levels increased in Zn-deficient dams. We concluded that long-term changes in dietary Zn down-regulate PPII activity independently of T3, increasing thyrotropin serum concentration, overall resembling sub-clinical hypothyroidismes_ES
dc.subject.koThyroid axises_ES
dc.subject.koZn deficiencyes_ES
dc.subject.koPPII enzymees_ES
dc.subject.koTSHes_ES
dc.subject.koAdenohypophysises_ES
dc.subject.koSubclinical hypothyroidismes_ES


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