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Mct8 and trh co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in rats

dc.creatorAlvarez-Salas, Elena
dc.creatorMengod, Guadalupe, García-Luna, Cinthia
dc.creatorSoberanes-Chávez, Paulina
dc.creatorMatamoros-Trejo, Gilberto
dc.creatorDe Gortari, Patricia
dc.date.accessioned2017-06-29T03:57:39Z
dc.date.available2017-06-29T03:57:39Z
dc.date.issued2016es_ES
dc.identifier2810es_ES
dc.identifier.issn0143-4179es_ES
dc.identifier.urihttps://doi.org/10.1016/j.npep.2015.11.001es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4659
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherAmsterdam : Elsevieres_ES
dc.relation56, 33-40 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnorexia/metabolismes_ES
dc.subject.meshDehydrationes_ES
dc.subject.meshMalees_ES
dc.subject.meshMonocarboxylic Acid Transporters/metabolismes_ES
dc.subject.meshNeurons/metabolismes_ES
dc.subject.meshParaventricular Hypothalamic Nucleus/metabolismes_ES
dc.subject.meshRNA, Messenger/metabolismes_ES
dc.subject.meshRatses_ES
dc.subject.meshThyrotropin-Releasing Hormone/metabolismes_ES
dc.titleMct8 and trh co-expression throughout the hypothalamic paraventricular nucleus is modified by dehydration-induced anorexia in ratses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationMolecular Neurophysiology, Department of Neuroscience Research, National Institute of Psychiatry Ramón de la Fuente Muñiz (INPRFM), Méxicoes_ES
dc.contributor.emailgmtrejor@imp.edu.mx, garcialuna@imp.edu.mx, gmtrejo@imp.edu.mx, gortari@imp.edu.mx,es_ES
dc.relation.jnabreviadoNEUROPEPTIDESes_ES
dc.relation.journalNeuropeptideses_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2016es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1532-2785es_ES
dc.identifier.doi10.1016/j.npep.2015.11.001es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaThyrotropin-releasing hormone (TRH) is a neuropeptide with endocrine and neuromodulatory effects. TRH from the paraventricular hypothalamic nucleus (PVN) participates in the control of energy homeostasis; as a neuromodulator TRH has anorexigenic effects. Negative energy balance decreases PVN TRH expression and TSH concentration; in contrast, a particular model of anorexia (dehydration) induces in rats a paradoxical increase in TRH expression in hypophysiotropic cells from caudal PVN and high TSH serum levels, despite their apparent hypothalamic hyperthyroidism and low body weight. We compared here the mRNA co-expression pattern of one of the brain thyroid hormones' transporters, the monocarboxylate transporter-8 (MCT8) with that of TRH in PVN subdivisions of dehydration-induced anorexic (DIA) and control rats. Our aim was to identify whether a low MCT8 expression in anorexic rats could contribute to their high TRH mRNA content. We registered daily food intake and body weight of 7-day DIA and control rats and analyzed TRH and MCT8 mRNA co-expression throughout the PVN by double in situ hybridization assays. We found that DIA rats showed increased number of TRHergic cells in caudal PVN, as well as a decreased percentage of TRH-expressing neurons that co-expressed MCT8 mRNA signal. Results suggest that the reduced proportion of double TRH/MCT8 expressing cells may be limiting the entry of hypothalamic triiodothyronine to the greater number of TRH-expressing neurons from caudal PVN and be in part responsible for the high TRH expression in anorexia rats and for the lack of adaptation of their hypothalamic-pituitary-thyroid axis to their low food intakees_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koMonocarboxylate transporter-8es_ES
dc.subject.koThyrotropin-releasing hormonees_ES
dc.subject.koAnorexiaes_ES
dc.subject.koHypothalamic paraventricular nucleuses_ES


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