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Low-dose amphotericin B with murine dialyzable spleen extracts protects against systemic candida infection in mice 

dc.creatorRobledo Avila, Frank
dc.creatorLimon Flores, Alberto
dc.creatorPavon Romero, Lenin
dc.creatorHernandez Pando, Rogelio
dc.creatorEstrada Parra, Sergio
dc.creatorEstrada Garcia, Iris
dc.creatorPerez Tapia, Sonia
dc.date.accessioned2017-06-29T03:57:20Z
dc.date.available2017-06-29T03:57:20Z
dc.date.issued2013es_ES
dc.identifier2807es_ES
dc.identifier.issn0022-1767es_ES
dc.identifier.uries_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4656
dc.identifier.urihttps://doi.org/10.1155/2013/194064es_ES
dc.language.isoenges_ES
dc.publisherBethesda, MD : American Association of Immunologistses_ES
dc.relation190, 1-8 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleLow-dose amphotericin B with murine dialyzable spleen extracts protects against systemic candida infection in mice es_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationEscuela Nacl Ciencias Biol, Mexico City, DF, Mexicoes_ES
dc.contributor.emailes_ES
dc.relation.jnabreviadoJ IMMUNOLes_ES
dc.relation.journalThe Journal of Immunologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1550-6606es_ES
dc.identifier.doi10.1155/2013/194064es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaCandida albicans causes opportunistic systemic infections with high mortality (30%–50%). Despite significant nephrotoxicity, amphotericin (AmB) is still used for the treatment of this serious fungal infection. Therefore, alternative treatments are urgently needed. Dialyzable leukocyte extracts have been used successfully to treat patients with mucocutaneous candidiasis, but their effectiveness in systemic candidiasis has not been evaluated. In this study, low-doseAmB(0.1mg/kg) plus 10 pg ofmurine dialyzable spleen extracts (mDSE) were tested in a systemic candidiasis mouse model. Survival, tissue fungal burden, kidney damage, kidney cytokines, and serum levels of IL-6 and hepcidin were evaluated. Our results showed that the combined treatment of low-dose AmB plus mDSE improved survival and reduced kidney fungal burden and histopathology; these effects correlated with increased kidney concentration of IFN-훾 and TGF-훽1, decreased levels of TNF-훼, IL-6, and IL-10, as well as high levels of systemic IL-6 and hepcidin. Low-dose AmB and mDSE synergized to clear the infectious agent and reduced tissue damage, confirming the efficacy of a low dose of AmB, which might decrease the risk of drug toxicity. Further studies are necessary to explore these findings and its implications in future therapeutic approaches.es_ES
dc.subject.meshmes_ES
dc.subject.koes_ES


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