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Long-term behavioral consequences of prenatal binge toluene exposure in adolescent rats

dc.creatorLópez-Rubalcava, C.
dc.creatorChávez-Alvarez, K.
dc.creatorHuerta-Rivas, A. G.
dc.creatorPáez-Martínez, N.
dc.creatorBowen, S. E.
dc.creatorCruz, S. L.
dc.date.accessioned2017-06-29T03:57:10Z
dc.date.available2017-06-29T03:57:10Z
dc.date.issued2014es_ES
dc.identifier2805es_ES
dc.identifier.issn2090-8334es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4654
dc.identifier.urihttps://doi.org/10.4303/jdar/235797es_ES
dc.language.isoenges_ES
dc.publisherCairo : Ashdin Publishing Corporationes_ES
dc.relation3, 1-9 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleLong-term behavioral consequences of prenatal binge toluene exposure in adolescent ratses_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartment of Pharmacobiology, Centre for Research and Advanced Studies of the National Polytechnic Institute (Cinvestav-IPN), Calzada de los Tenorios 235, Col. Granjas Coapa, 14330 Mexico, DF, Mexicoes_ES
dc.contributor.emailslcruz@cinvestav.mxes_ES
dc.relation.jnabreviadoJ DRUG ALCOHOL RESes_ES
dc.relation.journalJournal of Drug and Alcohol Researches_ES
dc.identifier.placeEgiptoes_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2090-8342es_ES
dc.identifier.doi10.4303/jdar/235841es_ES
dc.description.abstractotrodiomaThe continued abuse of inhaled organic solvents, especially among women of childbearing age, raises the risk of long-term behavioral effects of maternal toluene abuse. In this study, the effects of short-term exposures to high toluene concentrations (i.e., “binges”) were tested in independent groups of adolescent rats with different toluene treatments: (a) acute: 30-day-old animals exposed for 30 min to air (A) or 6,000 ppm toluene (T); (b) prenatal and postnatal: rats exposed to T or A from gestation days 8–20 and re-exposed to T or A from postnatal day (PN) 22 to PN30 (A/A, T/A, A/T, and T/T, resp.). On PN30, animals were evaluated in different tests. Postnatal toluene exposure produced anxiolytic-like effects in the burying behavior test, and the T/T group received the highest number of electrical shocks. Antinociception was observed in the T, A/T, and T/T groups in the hotplate test. All toluene treatments impaired short-term memory in the object recognition test, but only postnatal exposure impaired long-term memory in the passive avoidance test. Sensitization occurred in the T/T group in locomotor activity. These results indicate that prenatal exposure to a concentration of toluene that does not produce evident malformations can modify behavioral toluene’s effects in adolescent rats.es_ES
dc.subject.koInhalantses_ES
dc.subject.koSolventses_ES
dc.subject.koToluenees_ES
dc.subject.koPrenatal exposurees_ES
dc.subject.koAdolescencees_ES
dc.subject.koSensitizationes_ES


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