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Long-lasting effects of GABA infusion into the cerebral cortex of the rat

dc.creatorMontiel, Teresa
dc.creatorAlmeida, Daniel
dc.creatorArango, Iván
dc.creatorCalixto, Eduardo
dc.creatorCasasola, César
dc.creatorBrailowsky, Simón
dc.date.accessioned2017-06-29T03:57:04Z
dc.date.available2017-06-29T03:57:04Z
dc.date.issued2000es_ES
dc.identifier2804es_ES
dc.identifier.issn2090-5904es_ES
dc.identifier.urihttps://doi.org/10.1155/NP.2000.1es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4653
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherNew York, NY : Hindawi Pub. Corpes_ES
dc.relation7 (1-2) 1-8 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnisomycin/pharmacologyes_ES
dc.subject.meshCerebral Cortex/drug effectses_ES
dc.subject.meshConvulsants/pharmacologyes_ES
dc.subject.meshElectric Stimulationes_ES
dc.subject.meshEpilepsy/chemically inducedes_ES
dc.subject.meshEpilepsy/prevention and controles_ES
dc.subject.meshIn Vitro Techniqueses_ES
dc.subject.meshInjectionses_ES
dc.subject.meshLong-Term Potentiationes_ES
dc.subject.meshMalees_ES
dc.subject.meshPentylenetetrazole/pharmacologyes_ES
dc.subject.meshProtein Synthesis Inhibitors/pharmacologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshSubstance Withdrawal Syndrome/prevention and controles_ES
dc.subject.meshTime Factorses_ES
dc.subject.meshgamma-Aminobutyric Acid/adverse effectses_ES
dc.subject.meshgamma-Aminobutyric Acid/pharmacologyes_ES
dc.titleLong-lasting effects of GABA infusion into the cerebral cortex of the rates_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de México (UNAM), Méxicoes_ES
dc.contributor.emailtmontiel@ifisiol.unam.mxes_ES
dc.relation.jnabreviadoNEURAL PLASTes_ES
dc.relation.journalNeural Plasticityes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2000es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1687-5443es_ES
dc.identifier.doi10.1155/NP.2000.1es_ES
dc.description.monthes_ES
dc.description.abstractotrodiomaIn electrophysiological terms, experimental models of durable information storage in the brain include long-term potentiation (LTP), long-term depression, and kindling. Protein synthesis correlates with these enduring processes. We propose a fourth example of long-lasting information storage in the brain, which we call the GABA-withdrawal syndrome (GWS). In rats, withdrawal of a chronic intracortical infusion of GABA, a ubiquitous inhibitory neurotransmitter, induced epileptogenesis at the infusion site. This overt GWS lasted for days. Anisomycin, a protein synthesis inhibitor, prevented the appearance of GWS in vivo. Hippocampal and neocortical slices showed a similar post-GABA hyperexcitability in vitro and an enhanced susceptibility to LTP induction. One to four months after the epileptic behavior disappeared, systemic administration of a subconvulsant dose of pentylenetetrazol produced the reappearance of paroxysmal activity. The long-lasting effects of tonic GABAA receptor stimulation may be involved in long-term information storage processes at the cortical level, whereas the cessation of GABAA receptor stimulation may be involved in chronic pathological conditions, such as epilepsy. Furthermore, we propose that GWS may represent a common key factor in the addiction to GABAergic agents (for example, barbiturates, benzodiazepines, and ethanol). GWS represents a novel form of neurono-glial plasticity. The mechanisms of this phenomenon remain to be understood.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koFocal epilepsyes_ES
dc.subject.koGABA-withdrawal syndromees_ES
dc.subject.koGWSes_ES
dc.subject.koMemoryes_ES
dc.subject.koMotor cortexes_ES
dc.subject.koGFAPes_ES
dc.subject.koPlasticityes_ES


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