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Lesion and electrical stimulation of the ventral tegmental area modify persistent nociceptive behavior in the rat

dc.creatorSotres-Bayón, Francisco
dc.creatorTorres-López, Edgar
dc.creatorLópez-Ávila, Alberto
dc.creatorDel Ángel, Rosendo
dc.creatorPellicer, Francisco
dc.date.accessioned2017-06-29T03:56:52Z
dc.date.available2017-06-29T03:56:52Z
dc.date.issued2001es_ES
dc.identifier2802es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttps://doi.org/10.1016/S0006-8993(01)02213-2es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4651
dc.language.isoenges_ES
dc.publisherAmsterdam Elsevier/North-Holland Biomedical Presses_ES
dc.relation898 (2) 342-349 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleLesion and electrical stimulation of the ventral tegmental area modify persistent nociceptive behavior in the rates_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Neurofisiología, Instituto Nacional de Psiquiatría, Camino a Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Mexicoes_ES
dc.contributor.emailpellicer@neuroserver.imp-neuro.edu.mxes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain Researches_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-6240es_ES
dc.identifier.doi10.1016/S0006-8993(01)02213-2es_ES
dc.description.abstractotrodiomaThe ventral tegmental area (VTA) has been traditionally related with the control of motor responses. However, some studies show that this area is also involved in the processing of nociceptive information. It has been reported that this nucleus participates in the dissociative analgesia phenomenon. In the few works where electrical stimulation and lesion of the VTA have been performed, evaluated with persistent or chronic pain related behaviors, contradictory results have been obtained. Thus, a more detailed analysis of the role of the VTA in persistent pain is needed. Two series of experiments were performed: lesions of this nucleus were done with radiofrequency, (bilaterally at two points per side using a temperature range from 50 to 808C), and the VTA was electrically stimulated (10 min daily over 5 days, 2 ms rectangular pulses at 100 Hz during 1 s every 5 s) using two different schemes:10 min before the induction of the nociceptive stimulus and 90 min after the induction of the nociceptive stimulus. The latter allowed us to distinguish if the VTA electrical stimulation had a distinctive antinociceptive effect when applied before or after the induction of the nociceptive stimulus on a persistent pain related behavioral response in the rat, the self injury behavior (SIB). Our results showed that VTA lesions enhanced the occurrence of SIB; while activation of this same nucleus by electrical stimulation after the nociceptive stimulus, but not before, facilitates the analgesic process, expressed as a 1 day delay in SIB onset. These results indicate that the VTA is a brain structure that plays a key role in the processing and modulation of persistent pain information. Data are discussed in terms of the relationship of the VTA with the affective component of paines_ES
dc.subject.koVentral tegmental areaes_ES
dc.subject.koAnterior cingulate cortexes_ES
dc.subject.koPersistent paines_ES
dc.subject.koDissociative analgesiaes_ES
dc.subject.koSelf injury behaviores_ES
dc.subject.koRates_ES
dc.subject.koPain modulationes_ES
dc.subject.koAnatomy and physiologyes_ES


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