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Isobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in mice

dc.creatorDéciga-Campos, Myrna
dc.creatorCortés, Alejandra
dc.creatorPellicer, Francisco
dc.creatorDíaz-Reval, Irene
dc.creatorGonzález-Trujano, María Eva
dc.date.accessioned2017-06-29T03:55:31Z
dc.date.available2017-06-29T03:55:31Z
dc.date.issued2014es_ES
dc.identifier2785es_ES
dc.identifier.issn0032-0943es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4634
dc.identifier.urihttp://doi.org/10.1055/s-0033-1360220es_ES
dc.language.isoenges_ES
dc.publisherStuttgart ; New York : George Thiemees_ES
dc.relation80 (2-3) 139-145 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalgesics-Chemistryes_ES
dc.subject.meshAnalgesics-Pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshDiclofenac-Chemistryes_ES
dc.subject.meshDiclofenac-Pharmacologyes_ES
dc.subject.meshDrug Evaluation, Preclinicales_ES
dc.subject.meshDrug Synergismes_ES
dc.subject.meshMicees_ES
dc.subject.meshTramadol-Chemistryes_ES
dc.subject.meshTramadol-Pharmacologyes_ES
dc.subject.meshTriterpenes-Chemistryes_ES
dc.subject.meshTriterpenes-Pharmacologyes_ES
dc.titleIsobolographic analysis of the antinociceptive interaction between ursolic acid and diclofenac or tramadol in micees_ES
dc.typeartículoes_ES
dc.contributor.affiliationSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México D. F., México.es_ES
dc.relation.jnabreviadoPLANTA MEDes_ES
dc.relation.journalPlanta Medicaes_ES
dc.identifier.placeAlemaniaes_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1439-0221es_ES
dc.identifier.doi10.1055/s-0033-1360220es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaIt is considered that natural products used in folk medicine can potentiate the effect of drugs. The aim of this study was to evaluate the pharmacological interaction between ursolic acid, a triterpene isolated from herbal medicines to treat pain, and the analgesics diclofenac or tramadol. Individual dose-response curves of the antinociceptive effect of these compounds were built to calculate the ED50, as well as the pharmacological interaction, by using isobolographic analysis. All treatments decreased significantly and in a dose-dependent manner the writhing behavior with ED50 values of 103.50 ± 19.66, 20.54 ± 6.05, and 9.60 ± 1.69 mg/kg, for ursolic acid, diclofenac, and tramadol, respectively. An isobolographic analysis allowed the characterization of the pharmacological interaction produced by a fixed ratio combination of 1 : 1 and 1 : 3 of equi-effective doses of these compounds. Theoretical antinociceptive ED50 values of ursolic acid-diclofenac were 62.12 ± 10.28 and 41.43 ± 6.69 mg/kg, respectively, not statistically different from those obtained experimentally (44.52 ± 5.25 and 44.89 ± 49.05 mg/kg, respectively), reporting an additive interaction. Theoretical antinociceptive ED50 values of ursolic acid-tramadol (56.56 ± 9.87 and 33.08 ± 5.07 mg/kg, respectively) were significantly lower than those observed experimentally (138.36 ± 49.05 and 67.34 ± 18.98 mg/kg, respectively) reporting antagonism in this interaction. Antinociceptive response obtained from isobolograms in the writhing test was corroborated by using formalin test in mice. Adverse effects such as gastric damage in the ursolic acid-diclofenac combination did not increase in an additive form similarly as with antinociception. Conversely, sedative response was significantly increased in the ursolic acid-tramadol combination. As observed in the formalin test, the antagonism on the antinociceptive response between ursolic acid and tramadol (1 : 1) was not reverted in the presence of the opioid antagonist naltrexone (1 mg/kg, i. p.). These results provide evidence for a differential pharmacological interaction, in which ursolic acid does not interfere with the antinociceptive effect of diclofenac but antagonizes that obtained with tramadol in an independent opioid mechanism. Therefore, medicinal plants containing abundant presence of ursolic acid may also modify efficacy in the alternative combinations for the pain therapy.es_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koDiclofenaces_ES
dc.subject.koIsobologrames_ES
dc.subject.koSynergismes_ES
dc.subject.koTramadoles_ES
dc.subject.koUrsolic acides_ES


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