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Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents

dc.creatorGalvez, Javier
dc.creatorEstrada-Reyes, Rosa
dc.creatorBenítez-king, Gloria
dc.creatorAraujo, Gabriela
dc.creatorOrozco, Sandra
dc.creatorFernandez-Mas, Rodrigo
dc.creatorAlmazan, Salvador
dc.creatorCalixto, Eduardo
dc.date.accessioned2017-06-29T03:55:20Z
dc.date.available2017-06-29T03:55:20Z
dc.date.issued2015es_ES
dc.identifier2783es_ES
dc.identifier.issn0922-6028es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4632
dc.identifier.urihttp://doi.org/10.3233/RNN-140486es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherAmsterdam : IOS Presses_ES
dc.relation33 (5) 683-700 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnticonvulsants/chemistryes_ES
dc.subject.meshAnticonvulsants/isolation and purificationes_ES
dc.subject.meshAnticonvulsants/pharmacologyes_ES
dc.subject.meshCA1 Region, Hippocampal/drug effectses_ES
dc.subject.meshCA1 Region, Hippocampal/physiologyes_ES
dc.subject.meshCerebral Cortex/drug effectses_ES
dc.subject.meshCerebral Cortex/physiopathologyes_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshDrug Evaluation, Preclinicales_ES
dc.subject.meshFlavonoids/chemistryes_ES
dc.subject.meshFlavonoids/isolation & purificationes_ES
dc.subject.meshFlavonoids/pharmacologyes_ES
dc.subject.meshGlucosides/chemistryes_ES
dc.subject.meshGlucosides/isolation & purificationes_ES
dc.subject.meshGlucosides/pharmacologyes_ES
dc.subject.meshHemiplegia/drug therapyes_ES
dc.subject.meshHemiplegia/pathologyes_ES
dc.subject.meshHemiplegia/physiopathologyes_ES
dc.subject.meshHypnotics and Sedatives/chemistryes_ES
dc.subject.meshHypnotics and Sedatives/isolation & purificationes_ES
dc.subject.meshHypnotics and Sedatives/pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshMotor Activity/drug effectses_ES
dc.subject.meshMotor Activity/physiologyes_ES
dc.subject.meshNeuroprotective Agents/chemistryes_ES
dc.subject.meshNeuroprotective Agents/isolation & purificationes_ES
dc.subject.meshNeuroprotective Agents/pharmacologyes_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshRecovery of Function/drug effectses_ES
dc.subject.meshRecovery of Function/physiologyes_ES
dc.subject.meshSeizures/drug therapyes_ES
dc.subject.meshSeizures/physiopathologyes_ES
dc.subject.meshTissue Culture Techniqueses_ES
dc.subject.meshgamma-Aminobutyric Acid/metabolismes_ES
dc.titleInvolvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodentses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratory of Phytopharmacology, National Institute of Psichiatry, D.F., Méxicoes_ES
dc.contributor.emailecalixto@imp.edu.mxes_ES
dc.relation.jnabreviadoRESTOR NEUROL NEUROSCIes_ES
dc.relation.journalRestorative Neurology Neurosciencees_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2015es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1878-3627es_ES
dc.identifier.doi10.3233/RNN-140486es_ES
dc.description.monthes_ES
dc.description.abstractotrodiomaPurpose: Characterization of sedative, possible anticonvulsant, and protective effects of Acacetin-7-O-glucoside (7-ACAG). Methods: 7-ACAG was separated and its purity was analyzed. Its sedative and anti-seizure effects (1, 10, 20, and 40 mg/kg) were evaluated in male mice. Synaptic responses were acquired from area CA1 of hippocampal slices obtained from male Wistar rats. Rats were subjected to stereotaxic surgeries to allow Electroencephalographic (EEG) recordings. Functional recovery was evaluated by measuring the time rats spent in completing the motor task. Then the rats were subjected to right hemiplegia and administered 7-ACAG (40 mg/kg) 1 h or 24 h after surgery. Brains of each group of rats were prepared for histological analysis. Results: Effective sedative doses of 7-ACAG comprised those between 20 and 40 mg/kg. Latency and duration of the epileptiform crisis were delayed by this flavonoid. 7-ACAG decreased the synaptic response in vitro, similar to Gamma-aminobutyric acid (GABA) effects. The flavonoid facilitated functional recovery. This data was associated with preserved cytoarchitecture in brain cortex and hippocampus. Conclusions: 7-ACAG possesses anticonvulsive and sedative effects. Results suggest that GABAergic activity and neuroprotection are involved in the mechanism of action of 7-ACAG and support this compound’s being a potential drug for treatment of anxiety or post-operative conditions caused by neurosurgeries.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koFlavonoidses_ES
dc.subject.koGABAAes_ES
dc.subject.koHemiplegiaes_ES
dc.subject.koFunctional recoveryes_ES


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