Mostrar el registro sencillo del ítem

Inhibition of peripheral nociceptors by aminoglycosides produces analgesia in inflammatory pain models in the rat

dc.creatorMercado, Francisco
dc.creatorAlmanza, Angélica
dc.creatorSimón-Arceo, Karina
dc.creatorLópez, Omar
dc.creatorVega, Rosario
dc.creatorCoffeen, Ulises
dc.creatorContreras, Bernardo
dc.creatorSoto, Enrique
dc.creatorPellicer Francisco
dc.date.accessioned2017-06-29T03:53:48Z
dc.date.available2017-06-29T03:53:48Z
dc.date.issued2015es_ES
dc.identifier2766es_ES
dc.identifier.issn0360-3997es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4615
dc.identifier.urihttps://doi.org/10.1007/s10753-014-9972-4es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherNew York, NY : Kluwer Academic/Plenum Publisherses_ES
dc.relation38 (2) 649-657 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAminoglycosides-Pharmacologyes_ES
dc.subject.meshAminoglycosides-Therapeutic usees_ES
dc.subject.meshAnalgesia-Methodses_ES
dc.subject.meshAnimalses_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshInflammation-Drug therapyes_ES
dc.subject.meshInflammation-Pathologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshNociceptors-Drug effectses_ES
dc.subject.meshNociceptors-Pathologyes_ES
dc.subject.meshPain-Drug therapyes_ES
dc.subject.meshPain-Pathologyes_ES
dc.subject.meshPain Measurement-Drug effectses_ES
dc.subject.meshPain Measurement-Methodses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.titleInhibition of peripheral nociceptors by aminoglycosides produces analgesia in inflammatory pain models in the rates_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101. Col. San Lorenzo Huipulco, Del. Tlalpan, México, D.F., México, C.P. 14370es_ES
dc.contributor.emailpellicer@imp.edu.mxes_ES
dc.relation.jnabreviadoINFLAMMATIONes_ES
dc.relation.journalInflammationes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2015es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1573-2576es_ES
dc.identifier.doi10.1007/s10753-014-9972-4es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaAminoglycosides (AGs) modulate nociceptors and ionic channels expressed in sensory neurons. The AG applied in situ could be useful to alleviate hyperalgesia in animal models of inflammatory pain. We tested streptomycin (ST) and neomycin (NEO) as analgesic agents applied in situ in rat paw inflammation caused by formalin or carrageenan administration. The action of ST and NEO on the action potential discharge produced by acidic stimuli in isolated dorsal root ganglion neurons was also studied in current-clamp recordings. In the formalin test, ST and NEO significantly reduced the nociceptive behaviour. ST reduced the N-(4-methyl-2-quinazolinyl)-guanidine (GMQ)-induced nociceptive behaviour, and NEO diminished the hyperalgesia to thermonociception and mechanonociception produced by CAR. In the current-clamp experiments, ST and NEO reduced the generation of action potentials when an acidic solution was applied. We conclude that ST and NEO produce analgesia to inflammatory pain, an effect that is due in part to the inhibition of ASIC activation in sensory neuronses_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koAminoglycosideses_ES
dc.subject.koNociceptiones_ES
dc.subject.koInflammationes_ES
dc.subject.koASICses_ES
dc.subject.koAnalgesiaes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem