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Hypothalamic-pituitary-adrenal axis function during perinatal depression

dc.creatorLeff Gelman, Phillipe
dc.creatorFlores-Ramos, Mónica
dc.creatorLópez-Martínez, Margarita
dc.creatorCruz Fuentes, Carlos
dc.creatorReyes Grajeda, Juan Pablo
dc.date.accessioned2017-06-29T03:53:00Z
dc.date.available2017-06-29T03:53:00Z
dc.date.issued2015es_ES
dc.identifier2756es_ES
dc.identifier.issn1673-7067es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4605
dc.identifier.urihttps://doi.org/10.1007/s12264-014-1508-2es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563683/es_ES
dc.language.isoenges_ES
dc.publisherBeijing, China : Science Presses_ES
dc.relation31 (3) 338-350 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleHypothalamic-pituitary-adrenal axis function during perinatal depressiones_ES
dc.typeartículoes_ES
dc.contributor.affiliationNational Institute of Perinatology, Mexico City, Mexicoes_ES
dc.contributor.emailpleff@ymail.comes_ES
dc.relation.jnabreviadoNEUROSCI BULLes_ES
dc.relation.journalNeuroscience Bulletines_ES
dc.identifier.placeChinaes_ES
dc.date.published2015es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1995-8218es_ES
dc.identifier.doi10.1007/s12264-014-1508-2es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaAbnormal function of the hypothalamic-pituitary-adrenal (HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol pro-inflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby.es_ES
dc.subject.koBraines_ES
dc.subject.koDepressiones_ES
dc.subject.koNeuroendocrinees_ES
dc.subject.koPregnancyes_ES
dc.subject.koStresses_ES
dc.subject.koGlucocorticoidses_ES


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