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Hippocampal hyperexcitability induced by GABA withdrawal is due to down-regulation of GABAA receptors
dc.creator | Casasola, C. | |
dc.creator | Bargas, J. | |
dc.creator | Arias-Montaño, J.A. | |
dc.creator | Calixto, E. | |
dc.creator | Montiel, T. | |
dc.creator | Galarraga, E. | |
dc.creator | Brailowsky, S. | |
dc.date.accessioned | 2017-06-29T03:52:27Z | |
dc.date.available | 2017-06-29T03:52:27Z | |
dc.date.issued | 2001 | es_ES |
dc.identifier | 2749 | es_ES |
dc.identifier.issn | 0920-1211 | es_ES |
dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/4598 | es_ES |
dc.identifier.uri | https://doi.org/10.1016/S0920-1211(01)00314-X | es_ES |
dc.description.abstract | es_ES | |
dc.language.iso | eng | es_ES |
dc.publisher | Amsterdam : Elsevier Science Publishers | es_ES |
dc.relation | 47 (3) 257-271 p. | es_ES |
dc.relation | versión del editor | es_ES |
dc.rights | acceso cerrado | es_ES |
dc.subject.mesh | es_ES | |
dc.title | Hippocampal hyperexcitability induced by GABA withdrawal is due to down-regulation of GABAA receptors | es_ES |
dc.title.alternative | es_ES | |
dc.type | artículo | es_ES |
dc.contributor.affiliation | Instituto de Fisiología Celular, UNAM, P.O. Box 70-253, Mexico City DF 04510, Mexico | es_ES |
dc.contributor.email | jbargas@ifisiol.unam.mx | es_ES |
dc.relation.jnabreviado | EPILEPSY RES | es_ES |
dc.relation.journal | Epilepsy Research | es_ES |
dc.identifier.place | Países Bajos | es_ES |
dc.date.published | 2001 | es_ES |
dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
dc.identifier.eissn | 1872-6844 | es_ES |
dc.identifier.doi | es_ES | |
dc.description.month | Dic | es_ES |
dc.description.abstractotrodioma | The sudden interruption of an intracortical instillation of exogenous -aminobutyric acid (GABA) generates an epileptic focus in mammals. Seizures elicited by GABA withdrawal (GW) last for weeks. A similar withdrawal-induced hyperexcitability is also produced by several GABAA receptor agonists. This work reports a quantitative analysis of GW-induced hyperexcitability produced in the hippocampus in vitro. GW produced a left-ward displacement of the input/output (I/O) function, suggesting that the postsynaptic component is predominant to explain the hyperexcitability. A decrease in the inhibitory efficacy of the GABAA receptor agonist, muscimol, confirmed that inhibition was impaired. Binding saturation experiments demonstrated a decrease in [3 H]-muscimol binding after GABA withdrawal showing a close correlation with the development of hyperexcitability. All these modifications coursed without changes in receptor affinity (KD) for muscimol or bicuculline as demonstrated by both binding studies and Schild analysis. It is concluded that, in the CA1 region of the hippocampus, it is the number of functional GABAA receptors, and not the affinity of the receptor, what is decreased during GW-induced hyperexcitability. | es_ES |
dc.subject.meshm | es_ES | |
dc.subject.kw | es_ES | |
dc.subject.ko | GABA | es_ES |
dc.subject.ko | GABAA receptors | es_ES |
dc.subject.ko | Epilepsy | es_ES |
dc.subject.ko | GABA withdrawal syndrome | es_ES |
dc.subject.ko | Withdrawal syndromes | es_ES |
dc.subject.ko | Hippocampus | es_ES |
dc.subject.ko | Benzodiazepine withdrawal | es_ES |
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