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Genome-wide association study of obsessive-compulsive disorder 

dc.creatorStewart, S.E.
dc.creatorYu, D.
dc.creatorScharf, J.M.
dc.creatorNeale, B.M.
dc.creatorFagerness, J.A.
dc.creatorMathews, C.A.
dc.creatorArnold, P.D.
dc.creatorEvans, P.D.
dc.creatorGamazon, E.R.
dc.creatorOsiecki, L.
dc.creatorMcGrath, L.
dc.creatorHaddad, S.
dc.creatorCrane, J.
dc.creatorHezel, D.
dc.creatorIllman, C.
dc.creatorMayerfeld, C.
dc.creatorKonkashbaev, A.
dc.creatorLiu, C.
dc.creatorPluzhnikov, A.
dc.creatorTikhomirov, A.
dc.creatorEdlund, C.K.
dc.creatorRauch, S.L.
dc.creatorMoessner, R.
dc.creatorFalkai, P.
dc.creatorMaier, W.
dc.creatorRuhrmann, S.
dc.creatorGrabe, H-J
dc.creatorLennertz, L.
dc.creatorWagner, M.
dc.creatorBellodi, L.
dc.creatorCavallini, M.C.
dc.creatorRichter, M.A.
dc.creatorCook, E.H., Jr.
dc.creatorKennedy, J.L.
dc.creatorRosenberg, D.
dc.creatorStein, D.J.
dc.creatorHemmings, S.M.J.
dc.creatorLochner, C.
dc.creatorAzzam, A.
dc.creatorChavira, D.A.
dc.creatorFournier, E.
dc.creatorGarrido, H.
dc.creatorSheppard, B.
dc.creatorUmana, P.
dc.creatorMurphy, D.L.
dc.creatorWendland, J.R.
dc.creatorVeenstra-VanderWeele, J.
dc.creatorDenys, D.
dc.creatorBlom, R.
dc.creatorDeforce, D.
dc.creatorVan Nieuwerburgh, F.
dc.creatorWestenberg, H.G.M.
dc.creatorWalitza, S.
dc.creatorEgberts, K.
dc.creatorRenner, T.
dc.creatorMiguel, E.C.
dc.creatorCappi, C.
dc.creatorHounie, A.G.
dc.creatorDo Rosario, M. Conceicao
dc.creatorSampaio, A.S.
dc.creatorVallada, H.
dc.creatorNicolini, H.
dc.creatorLanzagorta, N.
dc.creatorCamarena, B.
dc.creatorDelorme, R.
dc.creatorLeboyer, M.
dc.creatorPato, C.N.
dc.creatorPato, M.T.
dc.creatorVoyiaziakis, E.
dc.creatorHeutink, P.
dc.creatorCath, D.C.
dc.creatorPosthuma, D.
dc.creatorSmit, J.H.
dc.creatorSamuels, J.
dc.creatorBienvenu, O.J.
dc.creatorCullen, B.
dc.creatorFyer, A.J.
dc.creatorGrados, M.A.
dc.creatorGreenberg, B.D.
dc.creatorMcCracken, J.T.
dc.creatorRiddle, M.A.
dc.creatorWang, Y.
dc.creatorCoric, V.
dc.creatorLeckman, J.F.
dc.creatorBloch, M.
dc.creatorPittenger, C.
dc.creatorEapen, V.
dc.creatorBlack, D.W.
dc.creatorOphoff, R.A.
dc.creatorStrengman, E.
dc.creatorCusi, D.
dc.creatorTuriel, M.
dc.creatorFrau, F.
dc.creatorMacciardi, F.
dc.creatorGibbs, J.R.
dc.creatorCookson, M.R.
dc.creatorSingleton, A.
dc.creatorHardy, J.
dc.creatorCrenshaw, A.T.
dc.creatorParkin, M.A.
dc.creatorMirel, D.B.
dc.creatorConti, D V.
dc.creatorPurcell, S.
dc.creatorNestadt, G.
dc.creatorHanna, G.L.
dc.creatorJenike, M.A.
dc.creatorKnowles, J.A.
dc.creatorCox, N.
dc.creatorPauls, D.L.
dc.date.accessioned2017-06-29T03:50:39Z
dc.date.available2017-06-29T03:50:39Z
dc.date.issued2013es_ES
dc.identifier2732es_ES
dc.identifier.issn1359-4184es_ES
dc.identifier.uries_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4581
dc.identifier.urihttps://doi.org/10.1038/mp.2012.85
dc.language.isoenges_ES
dc.publisherNature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, Englandes_ES
dc.relation18 (7) 788-798 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleGenome-wide association study of obsessive-compulsive disorder es_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationUniv British Columbia, Dept Psychiat, OCD Clin, BCMHARI,CFRI, A3-118,938 West 28th Ave, Vancouver, BC V5Z 4H4, Canada.es_ES
dc.contributor.emailsevelynstewart@gmail.com; dpauls@pngu.mgh.harvard.edu es_ES
dc.relation.jnabreviadoMOL PSYCHIATRYes_ES
dc.relation.journalMolecular Psychiatryes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1476-5578es_ES
dc.identifier.doi10.1038/mp.2012.85 es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaObsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness with complex genetic etiology. The International OCD Foundation Genetics Collaborative (IOCDF-GC) is a multi-national collaboration established to discover the genetic variation predisposing to OCD. A set of individuals affected with DSM-IV OCD, a subset of their parents, and unselected controls, were genotyped with several different Illumina SNP microarrays. After extensive data cleaning, 1465 cases, 5557 ancestry-matched controls and 400 complete trios remained, with a common set of 469 410 autosomal and 9657 X-chromosome single nucleotide polymorphisms (SNPs). Ancestry-stratified case-control association analyses were conducted for three genetically-defined subpopulations and combined in two meta-analyses, with and without the trio-based analysis. In the case-control analysis, the lowest two P-values were located within DLGAP1 (P = 2.49 x 10(-6) and P = 3.44 x 10(-6)), a member of the neuronal postsynaptic density complex. In the trio analysis, rs6131295, near BTBD3, exceeded the genome-wide significance threshold with a P-value = 3.84 x 10(-8). However, when trios were meta-analyzed with the case-control samples, the P-value for this variant was 3.62 x 10(-5), losing genome-wide significance. Although no SNPs were identified to be associated with OCD at a genome-wide significant level in the combined trio-case-control sample, a significant enrichment of methylation QTLs (P < 0.001) and frontal lobe expression quantitative trait loci (eQTLs) (P = 0.001) was observed within the top-ranked SNPs (P < 0.01) from the trio-case-control analysis, suggesting these top signals may have a broad role in gene expression in the brain, and possibly in the etiology of OCD.es_ES
dc.subject.meshmes_ES
dc.subject.koDLGAPes_ES
dc.subject.kogenetices_ES
dc.subject.kogenomices_ES
dc.subject.koGWASes_ES
dc.subject.koneurodevelopmental disorderes_ES
dc.subject.koobsessive-compulsive disorderes_ES


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