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Gender-associated differential expression of cytokines in specific areas of the brain during helminth infection

dc.creatorLópez-Griego, Lorena
dc.creatorNava-Castro, Karen Elizabeth
dc.creatorLópez-Salazar, Valeria
dc.creatorHernández-Cervantes, Rosalía
dc.creatorTiempos Guzmán, Nelly
dc.creatorMuñiz-Hernández, Saé
dc.creatorHernández-Bello, Romel
dc.creatorBesedovsky, Hugo O.
dc.creatorPavón, Lenin
dc.creatorBecerril Villanueva, Luis Enrique
dc.creatorMorales-Montor, Jorge
dc.date.accessioned2017-06-29T03:50:31Z
dc.date.available2017-06-29T03:50:31Z
dc.date.issued2015es_ES
dc.identifier2731es_ES
dc.identifier.issn1079-9907es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4580
dc.identifier.urihttps://doi.org/10.1089/jir.2013.0141es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312792/es_ES
dc.language.isoenges_ES
dc.publisherLarchmont, NY : Mary Ann Liebertes_ES
dc.relation35 (2) 116-125 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleGender-associated differential expression of cytokines in specific areas of the brain during helminth infectiones_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , Mexico City, México .es_ES
dc.contributor.email jmontor66@biomedicas.unam.mx; jmontor66@hotmail.comes_ES
dc.relation.jnabreviadoJ INTERFERON CYTOKINE RESes_ES
dc.relation.journalJournal of Interferon and Cytokine Researches_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2015es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1557-7465es_ES
dc.identifier.doi10.1089/jir.2013.0141.es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaIntraperitoneal infection with Taenia crassiceps cysticerci in mice alters several behaviors, including sexual, aggressive, and cognitive function. Cytokines and their receptors are produced in the central nervous system (CNS) by specific neural cell lineages under physiological and pathological conditions, regulating such processes as neurotransmission. This study is aimed to determine the expression patterns of cytokines in various areas of the brain in normal and T. crassiceps-infected mice in both genders and correlate them with the pathology of the CNS and parasite counts. IL-4, IFN-γ, and TNF-α levels in the hippocampus and olfactory bulb increased significantly in infected male mice, but IL-6 was downregulated in these regions in female mice. IL-1β expression in the hippocampus was unaffected by infection in either gender. Our novel findings demonstrate a clear gender-associated pattern of cytokine expression in specific areas of the brain in mammals that parasitic infection can alter. Thus, we hypothesize that intraperitoneal infection is sensed by the CNS of the host, wherein cytokines are important messengers in the host–parasite neuroimmunoendocrine network.es_ES


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