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GABAA receptor agonist at the caudo-lateral peribrachial area suppresses ponto-geniculo-occipital waves and its related states

dc.creatorRamírez-Salado, Ignacio
dc.creatorRivera-García, Ana Paula
dc.creatorVelázquez Moctezuma, Javier
dc.creatorJiménez Anguiano, Anabel
dc.creatorPellicer, Francisco
dc.date.accessioned2017-06-29T03:50:22Z
dc.date.available2017-06-29T03:50:22Z
dc.date.issued2014
dc.identifier2729es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4578
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2014.06.024es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherTarrytown, NY : Elsevieres_ES
dc.relation124, 333-340 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCarbachol-Administration & dosagees_ES
dc.subject.meshCarbachol-Pharmacologyes_ES
dc.subject.meshCatses_ES
dc.subject.meshGABA-A Receptor Agonists-Pharmacologyes_ES
dc.subject.meshGlutamic Acid-Administration & dosagees_ES
dc.subject.meshGlutamic Acid-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMicroinjectionses_ES
dc.subject.meshMuscimol-Administration & dosagees_ES
dc.subject.meshMuscimol-Pharmacologyes_ES
dc.subject.meshPons-Drug effectses_ES
dc.subject.meshPons-Physiologyes_ES
dc.subject.meshSleep, REM-Drug effectses_ES
dc.subject.meshWakefulnesses_ES
dc.titleGABAA receptor agonist at the caudo-lateral peribrachial area suppresses ponto-geniculo-occipital waves and its related stateses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDoctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340, Mexico; Laboratorio de Cronobiología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370, Mexicoes_ES
dc.contributor.emailsalado@imp.edu.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology, Biochemistry, and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2014.06.024es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaPURPOSE: In order to explore the potential role of GABA, acetylcholine and glutamate in the caudo-lateral peribrachial area (C-PBL) over Rapid-Eye-Movement sleep (REM) onset and maintenance as well as on synchronized sleep with ponto-geniculo-occipital (PGO) waves (SP) in cats, a muscimol, carbachol and L-glutamate local application was performed and behavioral states were assessed. METHODS: Fourteen chronically implanted, adult, male cats underwent a 23 hour polysomnographic recording after 3 pharmacological manipulations: carbachol, muscimol and L-glutamate. Each cat received all three drugs randomly with a seven day interval. RESULTS: 1) Carbachol increases waking, SP and REM sleep while decreases slow wave sleep (SWS). 2) Muscimol decreases SP percentage and number while increases REM sleep onset. 3) Carbachol facilitates PGO activity and increases the latency to both SWS1 and REM sleep but enhances PGO activity while muscimol decreases it. CONCLUSIONS: Acetylcholine promotes PGO related states (SP as well as REM sleep), while GABA reduces only SP and specifically PGOs.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koCaudo-lateral peribrachial area (C-PBL)es_ES
dc.subject.koCarbacholes_ES
dc.subject.koMuscimoles_ES
dc.subject.koGlutamatees_ES
dc.subject.koPonto-geniculo-occipital waves (PGO)es_ES
dc.subject.koSynchronized sleep with PGO waves (SP)es_ES


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