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Forced swim and chronic variable stress reduced hippocampal cell survival in OVX female rats

dc.creatorVega-Rivera, N.M.
dc.creatorFernandez-Guasti, A.
dc.creatorRamirez-Rodriguez, G.
dc.creatorEstrada-Camarena, E.
dc.date.accessioned2017-06-29T03:50:03Z
dc.date.available2017-06-29T03:50:03Z
dc.date.issued2014
dc.identifier2725es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbr.2014.05.033es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4574
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherAmsterdam, Elsevier/North-Holland Biomedical Presses_ES
dc.relation270 (15) 248-255 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshChronic variable stresses_ES
dc.subject.meshForced swimming testes_ES
dc.subject.meshCell proliferationes_ES
dc.subject.meshCell survivales_ES
dc.subject.meshCorticosteronees_ES
dc.subject.meshOvariectomyes_ES
dc.titleForced swim and chronic variable stress reduced hippocampal cell survival in OVX female ratses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Neuropsicofarmacologia, Instituto Nacional de Psiquiatriaes_ES
dc.contributor.emailestrada@imp.edu.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7549es_ES
dc.identifier.doi10.1016/j.bbr.2014.05.033es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaStress and glucocorticoids induce effects on neuronal and behavioral function. These effects may depend on the study design and importantly on the nature and duration of the stressor. We have previously observed that a single exposure to the forced swim test (FST) caused long-lasting effects on the HPA axis response and hippocampal cell survival. In despite that the FST and the chronic variable stress (CVS) paradigm are not strictly comparable; the aim of this study was to compare their effects on the respective depressive-like behavior, the serum corticosterone levels and cell proliferation and survival in ovariectomized female rats. Cell proliferation was determined by Ki67-labeling, while cell survival was analyzed with BrdU, a thymidine analog. The results showed that FST increased immobility and corticosterone levels at the same time that it decreased cell survival without modifying cell proliferation. In contrast, after 5 weeks of CVS there was a sharp reduction in sucrose intake, cell proliferation and survival, but a lack of effect on corticosterone levels. The FST produced a reduction on newborn cell survival analogous to that exerted by CVS. These data suggest that the FST could be considered as an attractive model to study some kind of stress-related disorders.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koCell proliferationes_ES
dc.subject.koCell survivales_ES
dc.subject.koChronic variable stresses_ES
dc.subject.koCorticosteronees_ES
dc.subject.koForced swimming testes_ES
dc.subject.koOvariectomyes_ES


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