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FMRFamide-related peptide expression in the vestibular-afferent neurons

dc.creatorMercado, Francisco
dc.creatorLópez, Iván
dc.creatorOrtega, Aida
dc.creatorAlmanza, Angélica
dc.creatorSoto, Enrique
dc.creatorVega, Rosario
dc.date.accessioned2017-06-29T03:49:59Z
dc.date.available2017-06-29T03:49:59Z
dc.date.issued2012
dc.identifier2724es_ES
dc.identifier.issn0304-3940es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4573
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2012.01.074es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherAmsterdam, Elsevier/North-Holland Limerick : Elsevier Scientific Publishers Irelandes_ES
dc.relation513 (1) 12-16 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshElectrophysiological Phenomenaes_ES
dc.subject.meshFMRFamide-Biosynthesises_ES
dc.subject.meshFluorescent Antibody Techniquees_ES
dc.subject.meshImmunoenzyme Techniqueses_ES
dc.subject.meshIn Vitro Techniqueses_ES
dc.subject.meshMalees_ES
dc.subject.meshNeurons, Afferent-Metabolismes_ES
dc.subject.meshPatch-Clamp Techniqueses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Long-Evanses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshSynapses-Physiologyes_ES
dc.subject.meshVestibule, Labyrinth-Cytologyes_ES
dc.subject.meshVestibule, Labyrinth-Innervationes_ES
dc.titleFMRFamide-related peptide expression in the vestibular-afferent neuronses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Apartado Postal 406, Puebla, Pue. C.P. 72000, Mexicoes_ES
dc.contributor.emailaxolotl 56@yahoo.com.mxes_ES
dc.relation.jnabreviadoNEUROSCI LETTes_ES
dc.relation.journalNeuroscience Letterses_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7972es_ES
dc.identifier.doi10.1016/j.neulet.2012.01.074es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaVestibular-afferent neurons innervate hair cells from the sensory epithelia of vestibular end-organs and their action-potential discharge dynamics are driven by linear and angular accelerations of the head. The electrical activity of the vestibular-afferent neurons depends on their intrinsic properties and on the synaptic input from hair cells and from the terminals of the efferent system. Here we report that vestibular-afferent neurons of the rat are immunoreactive to RFamide-related peptides, and that the stronger signal comes from calyx-shaped neuron dendrites, with no signal detected in hair cells or supporting cells. The whole-cell voltage clamp recording of isolated afferent neurons showed that they express robust acid-sensing ionic currents (ASICs). Extracellular multiunit recordings of the vestibular nerve in a preparation in vitro of the rat inner ear showed that the perfusion of FMRFamide (a snail ortholog of this family of neuropeptides) exerts an excitatory effect on the afferent-neurons spike-discharge rate. Because the FMRFamide cannot activate the ASIC but reduces its desensitization generating a more robust current, its effect indicates that the ASIC are tonically active in the vestibularafferent neurons and modulated by RFamide-like peptides.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koRF-amidees_ES
dc.subject.koSemicircular canales_ES
dc.subject.koHair celles_ES
dc.subject.koASICes_ES
dc.subject.koAmiloridees_ES
dc.subject.koAfferent synapsees_ES


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