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dc.creatorAlmanza, Angélica
dc.creatorMercado, Francisco
dc.creatorVega, Rosario
dc.creatorSoto, Enrique
dc.date.accessioned2017-06-29T03:49:28Z
dc.date.available2017-06-29T03:49:28Z
dc.date.issued2008es_ES
dc.identifier2716es_ES
dc.identifier.issn0364-3190es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4565
dc.identifier.urihttps://doi.org/10.1007/s11064-007-9565-9es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherNew York, NY : Kluwer Academic/Plenum Publisherses_ES
dc.relation33 (8) 1435-1441 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCalcium/metabolismes_ES
dc.subject.meshCalcium Channels/metabolismes_ES
dc.subject.meshHair Cells, Auditory/cytologyes_ES
dc.subject.meshHair Cells, Auditory/metabolismes_ES
dc.subject.meshHydrogen-Ion Concentrationes_ES
dc.subject.meshIon Channel Gating/physiologyes_ES
dc.subject.meshPatch-Clamp Techniqueses_ES
dc.subject.meshPotassium/metabolismes_ES
dc.subject.meshPotassium Channels/metabolismes_ES
dc.subject.meshProtonses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Long-Evanses_ES
dc.titleExtracellular pH modulates the voltage-dependent Ca2+ current and low threshold K+ current in hair cellses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto de Fisiología, Universidad Autónoma de Puebla (BUAP), Apartado Postal 406, Puebla 72000, Mexicoes_ES
dc.contributor.emailesoto@siu.buap.mxes_ES
dc.relation.jnabreviadoNEUROCHEM RESes_ES
dc.relation.journalNeurochemical Researches_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1573-6903es_ES
dc.identifier.doi10.1007/s11064-007-9565-9es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaExtracellular protons have been shown to modulate voltage-activated ionic channels. It has been proposed that synaptic modulation by exocytosed vesicular protons would be a characteristic feature of ribbon-type synapses. Type-I hair cells have a calyceal afferent junction with a diffusionally restricted synaptic cleft. These led us to study the action of extracellular pH changes on the voltage-activated Ca2+ and K+ currents evaluated using a whole-cell patch clamp in isolated cells. The amplitude of the Ca2+ and the K+ current were reduced by extracellular acidification, but without significant changes with extracellular alkalization. A shift in the voltage dependence to a more positive membrane potential was achieved at pH \6.8. Our results shows that the presynaptic K+ and Ca2+ currents are modulated by protons, indicating that protons released along with an afferent neurotransmitter would participate as a feedback mechanism in type-I hair cells.es_ES
dc.subject.koCalcium channeles_ES
dc.subject.koPotassium channeles_ES
dc.subject.koERGes_ES
dc.subject.koKCNQes_ES
dc.subject.koInner eares_ES
dc.subject.koVestibular endorganses_ES
dc.subject.koRibbon synapsees_ES
dc.subject.koSynaptices_ES
dc.subject.koAfferent synapsees_ES
dc.subject.koProtones_ES
dc.subject.koNeuromodulationes_ES
dc.subject.koNeurotransmitter releasees_ES


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