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Extracellular pH modulates the voltage-dependent Ca2+ current and low threshold K+ current in hair cells
dc.creator | Almanza, Angélica | |
dc.creator | Mercado, Francisco | |
dc.creator | Vega, Rosario | |
dc.creator | Soto, Enrique | |
dc.date.accessioned | 2017-06-29T03:49:28Z | |
dc.date.available | 2017-06-29T03:49:28Z | |
dc.date.issued | 2008 | es_ES |
dc.identifier | 2716 | es_ES |
dc.identifier.issn | 0364-3190 | es_ES |
dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/4565 | |
dc.identifier.uri | https://doi.org/10.1007/s11064-007-9565-9 | es_ES |
dc.description.abstract | es_ES | |
dc.language.iso | eng | es_ES |
dc.publisher | New York, NY : Kluwer Academic/Plenum Publishers | es_ES |
dc.relation | 33 (8) 1435-1441 p. | es_ES |
dc.relation | versión del editor | es_ES |
dc.rights | acceso cerrado | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Calcium/metabolism | es_ES |
dc.subject.mesh | Calcium Channels/metabolism | es_ES |
dc.subject.mesh | Hair Cells, Auditory/cytology | es_ES |
dc.subject.mesh | Hair Cells, Auditory/metabolism | es_ES |
dc.subject.mesh | Hydrogen-Ion Concentration | es_ES |
dc.subject.mesh | Ion Channel Gating/physiology | es_ES |
dc.subject.mesh | Patch-Clamp Techniques | es_ES |
dc.subject.mesh | Potassium/metabolism | es_ES |
dc.subject.mesh | Potassium Channels/metabolism | es_ES |
dc.subject.mesh | Protons | es_ES |
dc.subject.mesh | Rats | es_ES |
dc.subject.mesh | Rats, Long-Evans | es_ES |
dc.title | Extracellular pH modulates the voltage-dependent Ca2+ current and low threshold K+ current in hair cells | es_ES |
dc.title.alternative | es_ES | |
dc.type | artículo | es_ES |
dc.contributor.affiliation | Instituto de Fisiología, Universidad Autónoma de Puebla (BUAP), Apartado Postal 406, Puebla 72000, Mexico | es_ES |
dc.contributor.email | esoto@siu.buap.mx | es_ES |
dc.relation.jnabreviado | NEUROCHEM RES | es_ES |
dc.relation.journal | Neurochemical Research | es_ES |
dc.identifier.place | Estados Unidos | es_ES |
dc.date.published | 2008 | es_ES |
dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
dc.identifier.eissn | 1573-6903 | es_ES |
dc.identifier.doi | 10.1007/s11064-007-9565-9 | es_ES |
dc.description.month | Ago | es_ES |
dc.description.abstractotrodioma | Extracellular protons have been shown to modulate voltage-activated ionic channels. It has been proposed that synaptic modulation by exocytosed vesicular protons would be a characteristic feature of ribbon-type synapses. Type-I hair cells have a calyceal afferent junction with a diffusionally restricted synaptic cleft. These led us to study the action of extracellular pH changes on the voltage-activated Ca2+ and K+ currents evaluated using a whole-cell patch clamp in isolated cells. The amplitude of the Ca2+ and the K+ current were reduced by extracellular acidification, but without significant changes with extracellular alkalization. A shift in the voltage dependence to a more positive membrane potential was achieved at pH \6.8. Our results shows that the presynaptic K+ and Ca2+ currents are modulated by protons, indicating that protons released along with an afferent neurotransmitter would participate as a feedback mechanism in type-I hair cells. | es_ES |
dc.subject.ko | Calcium channel | es_ES |
dc.subject.ko | Potassium channel | es_ES |
dc.subject.ko | ERG | es_ES |
dc.subject.ko | KCNQ | es_ES |
dc.subject.ko | Inner ear | es_ES |
dc.subject.ko | Vestibular endorgans | es_ES |
dc.subject.ko | Ribbon synapse | es_ES |
dc.subject.ko | Synaptic | es_ES |
dc.subject.ko | Afferent synapse | es_ES |
dc.subject.ko | Proton | es_ES |
dc.subject.ko | Neuromodulation | es_ES |
dc.subject.ko | Neurotransmitter release | es_ES |
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