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Expression of muscarinic M1 and M2 receptors in the anterior cingulate cortex associated with neuropathic pain

dc.creatorOrtega-Legaspi, J. Manuel
dc.creatorLeón-Olea, Martha
dc.creatorde Gortari, Patricia
dc.creatorAmaya, María Isabel
dc.creatorCoffeen, Ulises
dc.creatorSimón-Arceo, Karina
dc.creatorPellicer, Francisco
dc.date.accessioned2017-06-29T03:49:24Z
dc.date.available2017-06-29T03:49:24Z
dc.date.issued2010es_ES
dc.identifier2715es_ES
dc.identifier.issn1090-3801es_ES
dc.identifier.urihttps://doi.org/10.1016/j.ejpain.2010.02.007es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4564
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherChichester, UK : Wileyes_ES
dc.relation14 (9) 901-910 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshGene Expression Regulation/drug effectses_ES
dc.subject.meshGyrus Cinguli/drug effectses_ES
dc.subject.meshGyrus Cinguli/metabolismes_ES
dc.subject.meshMalees_ES
dc.subject.meshMuscarinic Antagonists/pharmacologyes_ES
dc.subject.meshPain/drug therapyes_ES
dc.subject.meshPain/metabolismes_ES
dc.subject.meshPain Measurement/methodses_ES
dc.subject.meshPeripheral Nervous System Diseases/drug therapyes_ES
dc.subject.meshPeripheral Nervous System Diseases/metabolismes_ES
dc.subject.meshRNA, Messenger/biosynthesises_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptor, Muscarinic M1/antagonists and inhibitorses_ES
dc.subject.meshReceptor, Muscarinic M1/biosynthesises_ES
dc.subject.meshReceptor, Muscarinic M1/geneticses_ES
dc.subject.meshReceptor, Muscarinic M2/antagonists and inhibitorses_ES
dc.subject.meshReceptor, Muscarinic M2/biosynthesises_ES
dc.subject.meshReceptor, Muscarinic M2/geneticses_ES
dc.subject.meshScopolamine Hydrobromide/pharmacologyes_ES
dc.titleExpression of muscarinic M1 and M2 receptors in the anterior cingulate cortex associated with neuropathic paines_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología Integrativa, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente, Mexicoes_ES
dc.contributor.emailpellicer@imp.edu.mxes_ES
dc.relation.jnabreviadoEUR J PAINes_ES
dc.relation.journalEuropean Journal of Paines_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1532-2149es_ES
dc.identifier.doidoi:10.1016/j.ejpain.2010.02.007es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaThe anterior cingulate cortex (ACC) and muscarinic receptors modulate pain. This study investigates changes in the expression of muscarinic-1 and -2 receptors (M1R, M2R) in rats’ ACC (cg1-rostral- and cg2-caudal) using a model of neuropathic pain by denervation, measured as autotomy score (AS) for 8 days. Changes were analysed with painful stimuli and with scopolamine into the ACC prior to this scheme. We used reverse transcriptase-polymerase chain reaction (RT-PCR) and immunofluorescence to determine M1R and M2R’s mRNA and protein levels, respectively. Animals were divided in low, medium and high AS groups. Cg1 showed decreased mRNA levels for both M1R and M2R in the low AS group, as opposed to an increased expression in the medium and high AS groups. Both receptors correlated positively with AS in these groups. In the scopolamine-treated animals there was an increase in mRNA levels for both receptors in cg1, whereas in cg2, mRNA levels of M1R decreased in all the AS and scopolamine groups. The increased M2R mRNA in cg2 correlated with AS in the low, medium and high AS groups whereas all the scopolamine groups showed an increase. Immunoreactivity of the M2R in cg1 decreased in the medium AS group in comparison to controls but scopolamine treatment produced an increase in the medium scopolamine AS group compared to the medium AS group. The M1R in cg1 and both receptors in cg2 showed no immunoreactivity changes. These results highlight the role of the M2R in cg1 related to the degree of autotomy.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koNeuropathic paines_ES
dc.subject.koAcetylcholinees_ES
dc.subject.koMuscarinic receptorses_ES
dc.subject.koAnterior cingulate cortexes_ES
dc.subject.koNociceptiones_ES


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