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Exposure to toluene and stress during pregnancy impairs pups' growth and dams' lactation 

dc.contributor.advisorhttps://doi.org/10.1016/j.ntt.2013.07.011es_ES
dc.creatorSoberanes-Chavez, Paulina
dc.creatorLopez-Rubalcava, Carolina
dc.creatorde Gortari, Patricia
dc.creatorCruz, Silvia L.
dc.date.accessioned2017-06-29T03:49:17Z
dc.date.available2017-06-29T03:49:17Z
dc.date.issued2013es_ES
dc.identifier2713es_ES
dc.identifier.issn0892-0362es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.ntt.2013.07.011es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4562
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherPergamon-Elsevier Science LTD, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Englandes_ES
dc.relation40,  9-16 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleExposure to toluene and stress during pregnancy impairs pups' growth and dams' lactation es_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationCINVESTAV, Dept Farmacobiol, Calzada Tenorios 235, Mexico City 14330, DF, Mexicoes_ES
dc.contributor.emailslcruz@cinvestav.mx es_ES
dc.relation.jnabreviadoNEUROTOXICOL TERATOLes_ES
dc.relation.journalNeurotoxicology and Teratologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-9738es_ES
dc.identifier.doi10.1016/j.ntt.2013.07.011 es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaInhalant misuse starts at an early age, and a large number of users are women in reproductive age. This study investigates whether exposure to toluene, a commonly misused solvent, alone or combined with restraint stress during pregnancy, produces adverse effects in pregnant mice and their offspring during lactation and adulthood. Pregnant animals were exposed to either 8000 ppm toluene (30 min/twice daily from gestational days 7-19), restraint stress (three times/day during the same gestation period) or both; control mice were only exposed to air. Our results show that toluene, stress and their combination reduced body weight gain in pregnant females without changing food consumption. In the offspring, all treatments resulted in low body weight at weaning, but with the toluene and stress combination this effect was seen from birth. Weight deficiency could not be attributed to poor maternal behavior during the first 3 weeks of age, but to a reduction in pro-TRH mRNA expression in the hypothalamic paraventricular nucleus and serum prolactin levels in dams. After weaning, pups that were subjected to toluene and stress during gestation had lower body weight and ate less than control animals. In conclusion, the combined exposure to toluene and stress during pregnancy lead to more pronounced effects in dams and longer-lasting actions in pups than exposure to either toluene or stress. (C) 2013 Elsevier Inc. All rights reserved.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koToluenees_ES
dc.subject.koStresses_ES
dc.subject.koPrenatales_ES
dc.subject.koThyrotropin-releasing hormone (TRH)es_ES
dc.subject.koProlactines_ES
dc.subject.koInhalantses_ES


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