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dc.creatorCuartas Arias, Jorge Mauricio
dc.creatorPalacio Acosta, Carlos A.
dc.creatorGarcía Valencia, Jenny
dc.creatorMontoya, Gabriel J.
dc.creatorArango Viana, Juan C.
dc.creatorCampo Nieto, Omer
dc.creatorFlórez, Andrés F.
dc.creatorCamarena Medellin, Beatriz E.
dc.creatorRojas Montoya, Winston
dc.creatorLopez Jaramillo, Carlos A.
dc.creatorAchury Gutierrez, Javier
dc.creatorCruz Fuentes, Carlos
dc.creatorBedoya Berrio, Gabriel
dc.creatorRuiz-Linares, Andres
dc.date.accessioned2017-06-29T03:49:12Z
dc.date.available2017-06-29T03:49:12Z
dc.date.issued2011es_ES
dc.identifier2711es_ES
dc.identifier.issn0955-8829es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4560
dc.identifier.urihttps://doi.org/10.1097/YPG.0b013e3283437175es_ES
dc.language.isoenges_ES
dc.publisherLondon : Clinical Neuroscience Publishers ; Colchester, Essex, UK : Distributed by Portland Press, [1990-es_ES
dc.relation21 (3) 115-124 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleExploring epistasis in candidate genes for antisocial personality disorderes_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartment of Psychiatry, Faculty of Medicinees_ES
dc.contributor.emailmauricio.cuartas@siu.udea.edu.coes_ES
dc.relation.jnabreviadoPSYCHIATR GENETes_ES
dc.relation.journalPsychiatric Geneticses_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1473-5873es_ES
dc.identifier.doi10.1097/YPG.0b013e3283437175es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaObjective To identify and characterize high-order gene-togene interactions in antisocial personality disorder (ASPD). Methods Participants for case–control study were selected from the inmate male population in Bellavista prison from Medellin. The study included 310 individuals with ASPD and 200 with no ASPD. Diagnoses were made according to a best-estimate procedure based on a semistructured interview (diagnostic interview for genetic studies 3.0). We genotyped some single-nucleotide polymorphisms in candidate genes with main serotonin pathway effects. The gene–gene interaction was examined using the multifactor dimensionality reduction method version 2.0.a. We assessed model sizes of 2 and 3 loci and counted the number of replicates that contained the causal loci in the final best model that was identified using 10-fold cross validation. Results We find epistatic interaction with catechol-O-methyl transferase (COMT), tryptophan hydroxylase, and 5-HTR2A (serotonin receptor) with ASPD. This data supports an important role of polymorphism in serotonin receptors and low enzyme activity of COMT for susceptibility to ASPD. Conclusion This study suggests that gene interactions between genetic variants in COMT, 5-HTR2A and tryptophan hydroxylase gene would be associated with ASPD and influence the dopamine rewards pathways and modulate serotonin levels in ASPD.es_ES
dc.subject.meshmAntisocial Personality Disorder-Geneticses_ES
dc.subject.meshmBase Sequencees_ES
dc.subject.meshmCase-Control Studieses_ES
dc.subject.meshmCatechol O-Methyltransferase-Geneticses_ES
dc.subject.meshmColombiaes_ES
dc.subject.meshmDNA Primerses_ES
dc.subject.meshmEpistasis, Genetices_ES
dc.subject.meshmHumanses_ES
dc.subject.meshmMalees_ES
dc.subject.meshmPolymorphism, Single Nucleotidees_ES
dc.subject.meshmReceptor, Serotonin, 5-HT2A-Geneticses_ES
dc.subject.meshmTryptophan Hydroxylase-Geneticses_ES
dc.subject.koAntisocial personality disorderes_ES
dc.subject.koCandidatees_ES
dc.subject.koGeneses_ES
dc.subject.koEpistasises_ES
dc.subject.koGenetic associationes_ES
dc.subject.koMultifactor dimensionality reductiones_ES


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