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Exploring epistasis in candidate genes for antisocial personality disorder
dc.creator | Cuartas Arias, Jorge Mauricio | |
dc.creator | Palacio Acosta, Carlos A. | |
dc.creator | García Valencia, Jenny | |
dc.creator | Montoya, Gabriel J. | |
dc.creator | Arango Viana, Juan C. | |
dc.creator | Campo Nieto, Omer | |
dc.creator | Flórez, Andrés F. | |
dc.creator | Camarena Medellin, Beatriz E. | |
dc.creator | Rojas Montoya, Winston | |
dc.creator | Lopez Jaramillo, Carlos A. | |
dc.creator | Achury Gutierrez, Javier | |
dc.creator | Cruz Fuentes, Carlos | |
dc.creator | Bedoya Berrio, Gabriel | |
dc.creator | Ruiz-Linares, Andres | |
dc.date.accessioned | 2017-06-29T03:49:12Z | |
dc.date.available | 2017-06-29T03:49:12Z | |
dc.date.issued | 2011 | es_ES |
dc.identifier | 2711 | es_ES |
dc.identifier.issn | 0955-8829 | es_ES |
dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/4560 | |
dc.identifier.uri | https://doi.org/10.1097/YPG.0b013e3283437175 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | London : Clinical Neuroscience Publishers ; Colchester, Essex, UK : Distributed by Portland Press, [1990- | es_ES |
dc.relation | 21 (3) 115-124 p. | es_ES |
dc.relation | versión del editor | es_ES |
dc.rights | acceso cerrado | es_ES |
dc.title | Exploring epistasis in candidate genes for antisocial personality disorder | es_ES |
dc.type | artículo | es_ES |
dc.contributor.affiliation | Department of Psychiatry, Faculty of Medicine | es_ES |
dc.contributor.email | mauricio.cuartas@siu.udea.edu.co | es_ES |
dc.relation.jnabreviado | PSYCHIATR GENET | es_ES |
dc.relation.journal | Psychiatric Genetics | es_ES |
dc.identifier.place | Inglaterra | es_ES |
dc.date.published | 2011 | es_ES |
dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
dc.identifier.eissn | 1473-5873 | es_ES |
dc.identifier.doi | 10.1097/YPG.0b013e3283437175 | es_ES |
dc.description.month | Jun | es_ES |
dc.description.abstractotrodioma | Objective To identify and characterize high-order gene-togene interactions in antisocial personality disorder (ASPD). Methods Participants for case–control study were selected from the inmate male population in Bellavista prison from Medellin. The study included 310 individuals with ASPD and 200 with no ASPD. Diagnoses were made according to a best-estimate procedure based on a semistructured interview (diagnostic interview for genetic studies 3.0). We genotyped some single-nucleotide polymorphisms in candidate genes with main serotonin pathway effects. The gene–gene interaction was examined using the multifactor dimensionality reduction method version 2.0.a. We assessed model sizes of 2 and 3 loci and counted the number of replicates that contained the causal loci in the final best model that was identified using 10-fold cross validation. Results We find epistatic interaction with catechol-O-methyl transferase (COMT), tryptophan hydroxylase, and 5-HTR2A (serotonin receptor) with ASPD. This data supports an important role of polymorphism in serotonin receptors and low enzyme activity of COMT for susceptibility to ASPD. Conclusion This study suggests that gene interactions between genetic variants in COMT, 5-HTR2A and tryptophan hydroxylase gene would be associated with ASPD and influence the dopamine rewards pathways and modulate serotonin levels in ASPD. | es_ES |
dc.subject.meshm | Antisocial Personality Disorder-Genetics | es_ES |
dc.subject.meshm | Base Sequence | es_ES |
dc.subject.meshm | Case-Control Studies | es_ES |
dc.subject.meshm | Catechol O-Methyltransferase-Genetics | es_ES |
dc.subject.meshm | Colombia | es_ES |
dc.subject.meshm | DNA Primers | es_ES |
dc.subject.meshm | Epistasis, Genetic | es_ES |
dc.subject.meshm | Humans | es_ES |
dc.subject.meshm | Male | es_ES |
dc.subject.meshm | Polymorphism, Single Nucleotide | es_ES |
dc.subject.meshm | Receptor, Serotonin, 5-HT2A-Genetics | es_ES |
dc.subject.meshm | Tryptophan Hydroxylase-Genetics | es_ES |
dc.subject.ko | Antisocial personality disorder | es_ES |
dc.subject.ko | Candidate | es_ES |
dc.subject.ko | Genes | es_ES |
dc.subject.ko | Epistasis | es_ES |
dc.subject.ko | Genetic association | es_ES |
dc.subject.ko | Multifactor dimensionality reduction | es_ES |
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