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Environmental enrichment induces neuroplastic changes in middle age female Balb/c mice and increases the hippocampal levels of BDNF, p-Akt and p-MAPK1/2

dc.creatorRamirez-Rodriguez, G.
dc.creatorOcana-Fernandez, M. A.
dc.creatorVega-Rivera, N. M.
dc.creatorTorres-Perez, O. M.
dc.creatorGomez-Sanchez, A.
dc.creatorEstrada-Camarena, E.
dc.creatorOrtiz-Lopez, L.
dc.date.accessioned2017-06-29T03:47:40Z
dc.date.available2017-06-29T03:47:40Z
dc.date.issued2014
dc.identifier2683es_ES
dc.identifier.issn0306-4522es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.neuroscience.2013.12.026es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4532
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisher[New York?] : Elsevier Sciencees_ES
dc.relation28 (260) 158-170 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshBDNFes_ES
dc.subject.meshCRes_ES
dc.subject.meshDCXes_ES
dc.subject.meshEDTAes_ES
dc.subject.meshENRes_ES
dc.subject.meshGCLes_ES
dc.subject.meshNHes_ES
dc.subject.meshPI3Kes_ES
dc.subject.meshTTBSes_ES
dc.subject.meshTween 20-TBSes_ES
dc.subject.meshZTes_ES
dc.subject.meshZeitgeber Timees_ES
dc.subject.meshAginges_ES
dc.subject.meshBrain-Derived Neurotrophic Factores_ES
dc.subject.meshCalretinines_ES
dc.subject.meshDoublecortines_ES
dc.subject.meshEnvironmental Enrichmentes_ES
dc.subject.meshEthylenediaminetetraacetic Acides_ES
dc.subject.meshGranular Cell Layeres_ES
dc.subject.meshHippocampuses_ES
dc.subject.meshNeurogenesises_ES
dc.subject.meshNeuroplasticityes_ES
dc.subject.meshNormal Housinges_ES
dc.subject.meshPhosphatidylinositol-3-Kinasees_ES
dc.titleEnvironmental enrichment induces neuroplastic changes in middle age female Balb/c mice and increases the hippocampal levels of BDNF, p-Akt and p-MAPK1/2es_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatry Ramon de la Fuente Munizes_ES
dc.contributor.emailgbernabe@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROSCIENCEes_ES
dc.relation.journalNeurosciencees_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7544es_ES
dc.identifier.doi10.1016/j.neuroscience.2013.12.026es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaHippocampus is one of the brain regions in which neuroplastic changes occur. Paradigms such as environmental enrichment (ENR) have been used to prevent or delay the neuroplastic changes of the hippocampus during aging. Here, we investigated the beneficial effects of ENR on dendritic spines and hippocampal neurogenesis in middle age Balb/c mice. ENR increased the number of dendritic spines, cell survival, and intermediate stages of the hippocampal neurodevelopment process. Also, ENR alters the distribution of cells involved in the neurogenic process along the dorsal-ventral dentate gyrus. In addition, ENR increased the proportion of cells with more mature dendritic morphology and net hippocampal neurogenesis. Whole-hippocampus protein extracts revealed that ENR increases the levels of BDNF, phospho-Akt and phospho-MAPK1/2, suggesting that the positive effects of ENR on neuroplasticity in middle age Balb/c mice involve the participation of these key-signaling proteins. Our results suggest that ENR is a relevant strategy to prevent neuroplastic decline by increasing the formation of both dendritic spines and new neurons in the hippocampus during middle agees_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koNeuroplasticityes_ES
dc.subject.koNeurogenesises_ES
dc.subject.koHippocampuses_ES
dc.subject.koAginges_ES
dc.subject.koBDNFes_ES


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