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Environmental enrichment increases doublecortin-associated new neurons and decreases neuronal death without modifying anxiety-like behavior in mice chronically exposed to toluene 

dc.creatorPaez-Martinez, Nayeli
dc.creatorFlores-Serrano, Zoraida
dc.creatorOrtiz-Lopez, Leonardo
dc.creatorRamirez-Rodriguez, Gerardo
dc.date.accessioned2017-06-29T03:47:36Z
dc.date.available2017-06-29T03:47:36Z
dc.date.issued2013es_ES
dc.identifier2682es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.uries_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4531
dc.language.isoenges_ES
dc.publisherElsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlandses_ES
dc.relation256,  432-440 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleEnvironmental enrichment increases doublecortin-associated new neurons and decreases neuronal death without modifying anxiety-like behavior in mice chronically exposed to toluene es_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInst Politecn Nacl, Escuela Super Med, Secc Posgrad & Invest, Mexico City 11340, DF, Mexicoes_ES
dc.contributor.emailnayepam@yahoo.com.mx es_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7549es_ES
dc.identifier.doi10.1016/j.bbr.2013.09.007 es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaToluene misuse is a health problem worldwide with broad effects at the level of the central nervous system; however, therapeutic alternatives for inhalant abusers are limited. Chronic use of volatile substances is associated with different neurological and cognitive alterations, being anxiety a psychiatric condition with high prevalence. At cellular level toluene reduces neurogenesis and induces neuronal death. On the other hand, environmental enrichment has demonstrated to produce positive effects at behavioral and neuronal levels. Thus, the aim of the present work was to model alterations occasioned after repeated exposure to toluene (anxiety, reduction in neurogenesis - measured as doublecortin-labeled cells - and neuronal death). Subsequently, the influence of environmental enrichment on these effects was evaluated. Adolescent mice were exposed to toluene vapors from 1 to 4 weeks. Effects on anxiety were evaluated with the burying behavior test, whereas neurogenesis and hippocampal cell death were analyzed with immunohistochemistry, using anti-doublecortin or anti-active-Caspase-3 antibodies, respectively. Results showed that chronic toluene exposure increased anxiety in the burying behavior test; additionally, toluene decreased neurogenesis and enhanced neuronal death. Environmental enrichment (EE) enhanced the anxiety like response in air-exposed mice but did not modify the toluene anxiety response. Additionally, EE enhanced neurogenesis in toluene-pretreated animals at the same level to that found in animals unexposed to toluene and decreased neuronal death. Overall, the present study showed that environmental enrichment positively impacts some effects produced by repeated exposure to toluene. (C) 2013 Elsevier B.V. All rights reserved.es_ES
dc.subject.meshmes_ES
dc.subject.koToluenees_ES
dc.subject.koEnvironmental enrichmentes_ES
dc.subject.koAnxietyes_ES
dc.subject.koNeurogenesises_ES
dc.subject.koDoublecortines_ES
dc.subject.koNeuronal deathes_ES


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