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Electric stimulation of the cingulum bundle precipitates onset of autotomy induced by inflammation in rat

dc.creatorPellicer, Francisco
dc.creatorLópez-Avila, Alberto
dc.creatorTorres-López, Edgar
dc.date.accessioned2017-06-29T03:47:23Z
dc.date.available2017-06-29T03:47:23Z
dc.date.issued1999es_ES
dc.identifier2678es_ES
dc.identifier.issn1090-3801es_ES
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1016/S1090-3801(99)90056-3/abstractes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4527
dc.language.isoenges_ES
dc.publisherChichester, UK : Wileyes_ES
dc.relation3 (3) 287-293 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleElectric stimulation of the cingulum bundle precipitates onset of autotomy induced by inflammation in rates_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Neurofisiología, lnstituto Mexicano de Psiquiatría, Camino a Xochimilco 101, San Lorenzo Huipulco, Tlalpan, México D.F., CP 14370, Fax: +655 99 80es_ES
dc.contributor.emailpellicer@neuroserver.imp-neuro.edu.mxes_ES
dc.relation.jnabreviadoEUR J PAINes_ES
dc.relation.journalEuropean Journal of Paines_ES
dc.identifier.placeInglaterraes_ES
dc.date.published1999es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1532-2149es_ES
dc.identifier.doi10.1016/S1090-3801(99)90056-3es_ES
dc.description.abstractotrodiomaThe purpose of this work was to test if electric stimulation of the cingulum bundle in animals subjected to a hindpaw inflammatory process precipitates the onset and enhances autotomy behaviour. Wistar rats were implanted with bipolar parallel electrodes in the boundary of the cingulum bundle. The inflammatory process was induced in all subjects by injection of carrageenan. The groups were: A, sham; B, implanted and stimulated 10 min daily for 7 days; C, implanted and stimulated 2 h daily, for 7 days. Both groups were injected with CAR 2 days after ending the stimulation period; and D, implanted and stimulated 10 min daily for 5 days, the first stimulation being simultaneous to CAR injection. Results show that 100% of the subjects in stimulated groups presented autotomy as compared with 66% in ‘the sham group. A significant shortening of the onset and increased rates in autotomy were observed in experimental groups (B, C and D) as compared to the sham group. We did not find differences between groups B and C, but there was an increment of autotomy in group D when compared with both B and C groups. We conclude that it is possible to facilitate the onset and to increase the intensity of the autotomy triggered by the inflammatory process with cingulum bundle electrical stimulation. The results also suggest that a fundamental condition to the development of the autotomy in this model is the presence of the noxious inflammatory processes_ES
dc.subject.koCingulumes_ES
dc.subject.koElectric stimulationes_ES
dc.subject.koAutotomyes_ES
dc.subject.koPaines_ES
dc.subject.koRates_ES
dc.subject.koInflammationes_ES


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