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Effects of progesterone on the content of CCR5 and CXCR4 coreceptors in PBMCs of seropositive and exposed but uninfected Mexican women to HIV-1

dc.creatorCabrera-Muñoz, Edith
dc.creatorFuentes-Romero, Luis L.
dc.creatorZamora-Chávez, Jorge
dc.creatorCamacho-Arroyo, Ignacio
dc.creatorSoto-Ramírez, Luis E.
dc.date.accessioned2017-06-29T03:46:55Z
dc.date.available2017-06-29T03:46:55Z
dc.date.issued2012es_ES
dc.identifier2669es_ES
dc.identifier.issn0960-0760es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4518
dc.identifier.urihttps://doi.org/10.1016/j.jsbmb.2012.02.001es_ES
dc.language.isoenges_ES
dc.publisherOxford ; New York : Pergamon, c1990-es_ES
dc.relation132(1-2) 66-72p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdultes_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshEstradiol-Bloodes_ES
dc.subject.meshEthnic Groupses_ES
dc.subject.meshFemalees_ES
dc.subject.meshHIV Infections-Metabolismes_ES
dc.subject.meshHIV Seropositivity-Metabolismes_ES
dc.subject.meshHIV-1es_ES
dc.subject.meshHormone Antagonists-Pharmacologyes_ES
dc.subject.meshHumanses_ES
dc.subject.meshLeukocytes, Mononucleares_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshMifepristone-Pharmacologyes_ES
dc.subject.meshProgesterone-Bloodes_ES
dc.subject.meshProgesterone-Pharmacologyes_ES
dc.subject.meshReceptors, CCR5-Metabolismes_ES
dc.subject.meshReceptors, CXCR4-Metabolismes_ES
dc.subject.meshReceptors, Progesterone-Antagonists & inhibitorses_ES
dc.titleEffects of progesterone on the content of CCR5 and CXCR4 coreceptors in PBMCs of seropositive and exposed but uninfected Mexican women to HIV-1es_ES
dc.typeartículoes_ES
dc.contributor.affiliationFacultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, México, Mexicoes_ES
dc.contributor.emailedarcamu@yahoo.com.mxes_ES
dc.relation.jnabreviadoJ STEROID BIOCHEM MOL BIOLes_ES
dc.relation.journalJournal of Steroid Biochemistry and Molecular Biologyes_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1879-1220es_ES
dc.identifier.doi10.1016/j.jsbmb.2012.02.001es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaCCR5 and CXCR4 play an important role in the establishment of HIV infection and disease progression. Caucasian people exposed to HIV but uninfected (EU) present a deletion of 32 bp in CCR5 that has not been reported in EU Hispanics from Latin America. Therefore, other factors besides mutations should be involved in this phenomenon. Studies in healthy women have shown that sex hormones such as progesterone (P) can modulate CCR5/CXCR4 expression through an unknown mechanism. The aim of this paper was to determine the role of P in the regulation of CCR5 and CXCR4 in peripheral blood mononuclear cells (PBMCs) of HIV-1 infected and EU women. We analyzed HIV-1-infected women with stable highly active antiretroviral therapy (HAART) with CD4+ cell counts <400/mm3 or diminution of 20%, EU and HIV-1 seronegative healthy controls. 5 × 106 PBMCs, from HIV-1 infected women, EU women and HIV-1 seronegative healthy controls were cultured and incubated with P (10 or 100 nM), RU486 (P antagonist, 1 M) or P (100 nM) + RU486 (1 M). CCR5/CXCR4 content was determined by Western blot. Densitometry data were analyzed using Mann–Whitney test. We found that CCR5 content was reduced by P in all groups. In contrast, CXCR4 content was increased by P in healthy controls and in HIV-1 infected women. Interestingly, CXCR4 content was reduced by P in EU. RU486 did not block P effects in any group. These findings suggest that P should participate in the acquisition and progression of HIV-1 infection by modulating CCR5 and CXCR4 expression. P could contribute to the resistance acquisition of HIV by EU through the down-regulation of both coreceptors.es_ES
dc.subject.koProgesteronees_ES
dc.subject.koProgesterone receptores_ES
dc.subject.koExposed uninfectedes_ES
dc.subject.koCCR5es_ES
dc.subject.koCXCR4es_ES
dc.subject.koHIVes_ES
dc.subject.koPBMCes_ES


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