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Effects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish(Oreochromis niloticus)

dc.creatorToledo-Ibarra, G.A.
dc.creatorDíaz-Resendiz, K.J.G.
dc.creatorPavón-Romero, L.
dc.creatorRojas-García, A.E.
dc.creatorMedina-Díaz, I.M.
dc.creatorGirón-Pérez, M.I.
dc.date.accessioned2017-06-29T03:46:48Z
dc.date.available2017-06-29T03:46:48Z
dc.date.issued2016es_ES
dc.identifier2667es_ES
dc.identifier.issn0165-2427es_ES
dc.identifier.urihttp://dx.doi.org/10.1016/j.vetimm.2016.05.010es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4516
dc.language.isoenges_ES
dc.relation176 58-63p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of diazinon on the lymphocytic cholinergic system of Nile tilapia fish(Oreochromis niloticus)es_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Inmunotoxicología, Universidad Autónoma de Nayarit, Secretaría de Investigación y Posgrado, Laboratorio de Inmunotoxicología, Boulevard Tepic-Xalisco s/n, Cd de la Cultura Amado Nervo, C.P. 63190, Tepic Nayarit, Mexicoes_ES
dc.contributor.emailivan giron@hotmail.comes_ES
dc.relation.jnabreviadoVET IMMUNOL IMMUNOPATHOLes_ES
dc.relation.journalVeterinary Immunology and Immunopathologyes_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2016es_ES
dc.identifier.eissn1873-2534es_ES
dc.identifier.doi10.1016/j.vetimm.2016.05.010es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaFish rearing under intensive farming conditions can be easily disturbed by pesticides, substances that have immunotoxic properties and may predispose to infections. Organophosphorus pesticides (OPs) are widely used in agricultural activities; however, the mechanism of immunotoxicity of these substances is unclear. The aim of this study was to evaluate the effect of diazinon pesticides (OPs) on the cholinergic system of immune cells as a possible target of OPimmunotoxicity. We evaluated ACh levels and cholinergic (nicotinic and muscarinic) receptor concentration. Additionally, AChE activity was evaluated in mono-nuclear cells of Nile tilapia (Oreochromis niloticus), a freshwater fish mostly cultivated in tropical regions around the world. The obtained results indicate that acute exposure to diazinon induces an increase in ACh concentration and a decrease in nAChR and mAChR concentrations and AChE activity in fish immune cells, This suggests that the non-neuronal lymphocytic cholinergic system may be the main target in the mechanism of OP immunotoxicity. This study contributes to the understanding of the mechanisms of immunotoxicity of pollutants and may help to take actions for animal health improvementes_ES
dc.subject.koAcetylcholinees_ES
dc.subject.koAcetylcholinesterasees_ES
dc.subject.koImmunotoxicityes_ES
dc.subject.koOrganophosphorus pesticideses_ES
dc.subject.koDiazinones_ES
dc.subject.koNile tilapia fishes_ES


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