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Effect of vagus nerve stimulation on electrical kindling in different stages of seizure severity in freely moving cats

dc.creatorMagdaleno-Madrigal, Victor Manuel
dc.creatorValdes-Cruz, Alejandro
dc.creatorMartinez-Vargas, David
dc.creatorAlmazan-Alvarado, Salvador
dc.creatorFernandez-Mas, Rodrigo
dc.date.accessioned2017-06-29T03:46:45Z
dc.date.available2017-06-29T03:46:45Z
dc.date.issued2014es_ES
dc.identifier2666es_ES
dc.identifier.issn0920-1211es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4515
dc.identifier.urihttps://doi.org/10.1016/j.eplepsyres.2013.10.012es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation108(1) 81-89p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleEffect of vagus nerve stimulation on electrical kindling in different stages of seizure severity in freely moving catses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología del Control y la Regulación, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.contributor.emailmaleno@imp.edu.mxes_ES
dc.relation.jnabreviadoEPILEPSY RESes_ES
dc.relation.journalEpilepsy Researches_ES
dc.identifier.placeNetherlandses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-6844es_ES
dc.identifier.doi10.1016/j.eplepsyres.2013.10.012es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaVagus nerve stimulation (VNS) is an adjunctive therapy for treating pharmacoresistant epilepsy. The present study analyze the effect of VNS on the epileptic activity of amygdala kindling (AK) in different seizure severity stages in freely moving cats. Fourteen adult male cats were used and were stereotaxically implanted in both amygdalae, in thalamic reticular nuclei and in prefrontal cortices. AK was developed by the application of 60Hz pulse trains that were one second in duration. VNS was applied the following day after the first stages were reached. This stimulation consisted of 10 pulse trains in the one-hour period (1min on/5min off) prior to AK. AK stimulation continued until all animals reached stage VI. The behavioral changes induced by VNS were transient and bearable. The animals showed relaxation of the nictitating membrane, ipsilateral anisocoria, swallowing and licking. Intermittent VNS application in stage I induced a delay in AK progression. The effect of VNS on the amygdala afterdischarge duration (AD) did not change progressively. VNS in stages II, III, and IV does not have an inhibitory effect on AK, and the AD further exhibited a progressive development. At the end of the generalized seizures, the animals presented with synchronized bilateral discharges of the spike-wave type (3Hz) and a behavioral "staring spell". Our results show that VNS applied during the different stages of seizure severity exerts an anti-epileptogenic effect in stage I but no anti-epileptogenic effect in stages II, III, and IV. These results suggest that VNS applied at stage I of kindling induces a delay of generalized convulsive activity.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koAmygdala kindlinges_ES
dc.subject.koAnti-epilpetogenices_ES
dc.subject.koPolyspikees_ES
dc.subject.koSpike-wave dischargees_ES
dc.subject.koVagus nerve stimulationes_ES


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