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Different amounts of ejaculatory activity, a natural rewarding behavior, induce differential mu and delta opioid receptor internalization in the rat's ventral tegmental area 

dc.creatorGarduno-Gutierrez, Rene
dc.creatorLeon-Olea, Martha
dc.creatorRodriguez-Manzo, Gabriela
dc.date.accessioned2017-06-29T03:45:12Z
dc.date.available2017-06-29T03:45:12Z
dc.date.issued2013es_ES
dc.identifier2639es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4488
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2013.10.015es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherElsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlandses_ES
dc.relation1541 22-32p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshEjaculation/physiologyes_ES
dc.subject.meshFluorescent Antibody Techniquees_ES
dc.subject.meshMalees_ES
dc.subject.meshProtein Transport/physiologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, Opioid, delta/metabolismes_ES
dc.subject.meshReceptors, Opioid, mu/metabolismes_ES
dc.subject.meshRewardes_ES
dc.subject.meshVentral Tegmental Area/metabolismes_ES
dc.titleDifferent amounts of ejaculatory activity, a natural rewarding behavior, induce differential mu and delta opioid receptor internalization in the rat's ventral tegmental area es_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationCinvestav Sede Sur, Dept Farmacobiol, Calzada Tenorios 235,Col Granjas Coapa, Mexico City 14330, DF, Mexico.es_ES
dc.contributor.emailgrodrigu@cinvestav.mx es_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-6240es_ES
dc.identifier.doi10.1016/j.brainres.2013.10.015 es_ES
dc.description.monthDic es_ES
dc.description.abstractotrodiomaOpioid receptors internalize upon specific agonist stimulation. The in vivo significance of receptor internalization is not well established, partly due to the limited in vivo models used to study this phenomenon. Ejaculation promotes endogenous opioid release which activates opioid receptors at the brain, including the mesolimbic system and medial preoptic area. The objective of the present work was to analyze if there was a correlation between the degree of in vivo mu (MOR) and delta opioid receptor (DOR) internalization in the ventral tegmental area and the execution of different amounts of ejaculatory behavior of male rats. To this aim, we analyzed the brains of rats that ejaculated once or six successive times and of sexually exhausted rats with an established sexual inhibition, using immunofluorescence and confocal microscopy. Results showed that MOR and DOR internalization increased as a consequence of ejaculation. There was a relationship between the amount of sexual activity executed and the degree of internalization for MOR, but not for DOR. MOR internalization was larger in rats that ejaculated repeatedly than in animals ejaculating only once. Significant DOR internalization was found only in animals ejaculating once. Changes in MOR, DOR and beta arrestin2 detection, associated to sexual activity, were also found. It is suggested that copulation to satiety might be useful as a model system to study the biological significance of receptor internalization. (C) 2013 Elsevier B.V. All rights reserved.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koIn vivo mu and delta opioid receptor internalizationes_ES
dc.subject.koEndogenous opioidses_ES
dc.subject.koEjaculationes_ES
dc.subject.kobeta-Arrestin2es_ES
dc.subject.koSexual exhaustiones_ES
dc.subject.koVentral tegmental areaes_ES


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