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Development of lifetime comorbidity in the WHO World Mental Health (WMH) Surveys

dc.creatorKessler, Ronald C.
dc.creatorOrmel, Johan
dc.creatorPetukhova, Maria
dc.creatorMcLaughlin, Katie A.
dc.creatorGreif Green, Jennifer
dc.creatorRusso, Leo J.
dc.creatorStein, Dan J.
dc.creatorZaslavsky, Alan M
dc.creatorAguilar-Gaxiola, Sergio
dc.creatorAlonso, Jordi
dc.creatorAndrade, Laura
dc.creatorBenjet, Corina
dc.creatorDe Girolamo, Giovanni
dc.creatorDe Graaf, Ron
dc.creatorDemyttenaere, Koen
dc.creatorFayyad, John
dc.creatorHaro, Josep Maria
dc.creatorHu, Chi yi
dc.creatorKaram, Aimee
dc.creatorLee, Sing
dc.creatorLepine, Jean-Pierre
dc.creatorMatchsinger, Herbert
dc.creatorMihaescu-Pintia, Constanta
dc.creatorPosada-Villa, Jose
dc.creatorSagar, Rajesh
dc.creatorÜstün, Bedirhan
dc.date.accessioned2017-06-29T03:44:58Z
dc.date.available2017-06-29T03:44:58Z
dc.date.issued2011es_ES
dc.identifier2634es_ES
dc.identifier.issn0003-990Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4483
dc.identifier.urihttp://doi.org/10.1001/archgenpsychiatry.2010.180es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation68(1) 90-100p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleDevelopment of lifetime comorbidity in the WHO World Mental Health (WMH) Surveyses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartment of Health Care Policy, Harvard Medical School, Boston, MA USAes_ES
dc.contributor.emailkessler@hcp.med.harvard.edues_ES
dc.relation.jnabreviadoARCH GEN PSYCHIATRYes_ES
dc.relation.journalArchives of general psychiatryes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1538-3636es_ES
dc.identifier.doi10.1001/archgenpsychiatry.2010.180es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaCONTEXT—Although numerous studies have examined the role of latent variables in the structure of comorbidity among mental disorders, none has examined their role in the development of comorbidity. OBJECTIVE—To study the role of latent variables in the development of comorbidity among 18 lifetime DSM-IV disorders in the WHO World Mental Health (WMH) surveys. SETTING/PARTICIPANTS—Nationally or regionally representative community surveys in 14 countries with a total of 21,229 respondents. MAIN OUTCOME MEASURES—First onset of 18 lifetime DSM-IV anxiety, mood, behavior, and substance disorders assessed retrospectively in the WHO Composite International Diagnostic Interview (CIDI). RESULTS—Separate internalizing (anxiety and mood disorders) and externalizing (behavior and substance disorders) factors were found in exploratory factor analysis of lifetime disorders. Consistently significant positive time-lagged associations were found in survival analyses for virtually all temporally primary lifetime disorders predicting subsequent onset of other disorders. Within-domain (i.e., internalizing or externalizing) associations were generally stronger than between-domain associations. The vast majority of time-lagged associations were explained by a model that assumed the existence of mediating latent internalizing and externalizing variables. Specific phobia and obsessive-compulsive disorder (internalizing) and hyperactivity disorder and oppositional-defiant disorder (externalizing) were the most important predictors. A small number of residual associations remained significant after controlling the latent variables. CONCLUSIONS—The good fit of the latent variable model suggests that common causal pathways account for most of the comorbidity among the disorders considered here. These common pathways should be the focus of future research on the development of comorbidity, although several important pair-wise associations that cannot be accounted for by latent variables also exist that warrant further focused studyes_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koes_ES


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