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Depressant effects of Salvia divinorum involve disruption of physiological sleep

dc.creatorGonzález-Trujano, María Eva
dc.creatorBrindis, Fernando
dc.creatorLópez-Ruiz, Edith
dc.creatorRamírez-Salado, Ignacio
dc.creatorMartínez, Adrián
dc.creatorPellicer, Francisco
dc.date.accessioned2017-06-29T03:44:40Z
dc.date.available2017-06-29T03:44:40Z
dc.date.issued2016es_ES
dc.identifier2628es_ES
dc.identifier.issn0951-418Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4477
dc.identifier.urihttps://doi.org/10.1002/ptr.5617es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation30(7) 1137–1145p. es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleDepressant effects of Salvia divinorum involve disruption of physiological sleepes_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. Sn. Lorenzo Huipulco14370, México, D. F., Méxicoes_ES
dc.contributor.emailevag@imp.edu.mx, pellicer@imp.edu.mxes_ES
dc.relation.jnabreviadoPHYTOTHER RESes_ES
dc.relation.journalPhytotherapy Researches_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2016es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1099-1573es_ES
dc.identifier.doi10.1002/ptr.5617es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaAlthough Salvia divinorum is traditionally known as a ‘mind-altering’ or psychoactive herb used, among others things, as a tranquilizer, this property has not been validated with regard to its efficacy and safety. The objective of this study is to provide evidence for the sedative effects of S. divinorum and discriminate the nature of the responsible constituents by examining different experimental models. A battery of tests, including the openfield, hole-board, exploration cylinder, plus-maze and sodium pentobarbital-induced hypnosis potentiation, were used in mice after administration of non-polar, medium polar and/or polar extracts of the plant (10, 30 and 100 mg/kg). Polysomnographic analysis in rats receiving an active medium polar extract (10 and 100 mg/kg) containing salvinorins was also assessed to study the effects of this plant on sleep architecture. All tested extracts produced significant sedative-like responses, although those of the medium polar extract were more pronounced in mice. The sedative effect of this latter extract, which contains a mixture of salvinorins, caused fragmented sleep architecture in rats by diminishing rapid eye movement (REM) sleep and increased the quiet awake stage at 10 and 100 mg/kg. Our results provide evidence that S. divinorum exhibits sedative-like depressant properties that alter physiological sleep architecturees_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koCentral nervous systemes_ES
dc.subject.koPolysomnographyes_ES
dc.subject.koREM-sleepes_ES
dc.subject.koSalvia divinorumes_ES
dc.subject.koSalvinorinses_ES
dc.subject.koSedative-hypnotices_ES


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