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Current Concepts in Neuroendocrine Disruption

dc.creatorLeón-Olea, Martha
dc.creatorMartyniuk, Christopher J.
dc.creatorOrlando, Edward F.
dc.creatorOttinger, Mary Ann
dc.creatorRosenfeld, Cheryl
dc.creatorWolstenholme, Jennifer
dc.creatorTrudeau, Vance L.
dc.date.accessioned2017-06-29T03:44:18Z
dc.date.available2017-06-29T03:44:18Z
dc.date.issued2014es_ES
dc.identifier2620es_ES
dc.identifier.issn0016-6480es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4469
dc.identifier.urihttps://doi.org/10.1016/j.ygcen.2014.02.005es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation203 158-173p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshEndocrine Disruptors/toxicityes_ES
dc.subject.meshEnvironmental Pollutants/toxicityes_ES
dc.subject.meshEpigenesis, Genetic/drug effectses_ES
dc.subject.meshNeurosecretory Systems/drug effectses_ES
dc.subject.meshPesticides/pharmacologyes_ES
dc.subject.meshReproduction/drug effectses_ES
dc.subject.meshVertebrateses_ES
dc.titleCurrent Concepts in Neuroendocrine Disruptiones_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Neuromorfología Funcional, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría, R.F.M., México D.F., Méxicoes_ES
dc.contributor.emailtrudeauv@uottawa.caes_ES
dc.relation.jnabreviadoGEN COMP ENDOCRINOLes_ES
dc.relation.journalGeneral and comparative endocrinologyes_ES
dc.identifier.placeEstados unidoses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1095-6840es_ES
dc.identifier.doi10.1016/j.ygcen.2014.02.005es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaIn the last few years, it has become clear that a wide variety of environmental contaminants have specific effects on neuroendocrine systems in fish, amphibians, birds and mammals. While it is beyond the scope of this review to provide a comprehensive examination of all of these neuroendocrine disruptors, we will focus on select representative examples. Organochlorine pesticides bioaccumulate in neuroendocrine areas of the brain that directly regulate GnRH neurons, thereby altering the expression of genes downstream of GnRH signaling. Organochlorine pesticides can also agonize or antagonize hormone receptors, adversely affecting crosstalk between neurotransmitter systems. The impacts of polychlorinated biphenyls are varied and in many cases subtle. This is particularly true for neuroedocrine and behavioral effects of exposure. These effects impact sexual differentiation of the hypothalamic-pituitary-gonadal axis, and other neuroendocrine systems regulating the thyroid, metabolic, and stress axes and their physiological responses. Weakly estrogenic and anti-androgenic pollutants such as bisphenol A, phthalates, phytochemicals, and the fungicide vinclozolin can lead to severe and widespread neuroendocrine disruptions in discrete brain regions, including the hippocampus, amygdala, and hypothalamus, resulting in behavioral changes in a wide range of species. Behavioral features that have been shown to be affected by one or more these chemicals include cognitive deficits, heightened anxiety or anxiety-like, sociosexual, locomotor, and appetitive behaviors. Neuroactive pharmaceuticals are now widely detected in aquatic environments and water supplies through the release of wastewater treatment plant effluents. The antidepressant fluoxetine is one such pharmaceutical neuroendocrine disruptor. Fluoxetine is a selective serotonin reuptake inhibitor that can affect multiple neuroendocrine pathways and behavioral circuits, including disruptive effects on reproduction and feeding in fish. There is growing evidence for the association between environmental contaminant exposures and diseases with strong neuroendocrine components, for example decreased fecundity, neurodegeneration, and cardiac disease. It is critical to consider the timing of exposures of neuroendocrine disruptors because embryonic stages of central nervous system development are exquisitely sensitive to adverse effects. There is also evidence for epigenetic and transgenerational neuroendocrine disrupting effects of some pollutants. We must now consider the impacts of neuroendocrine disruptors on reproduction, development, growth and behaviors, and the population consequences for evolutionary change in an increasingly contaminated world. This review examines the evidence to date that various so-called neuroendocrine disruptors can induce such effects often at environmentally-relevant concentrations.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koBisphenol Aes_ES
dc.subject.koGrowthes_ES
dc.subject.koOrganochlorine pesticideses_ES
dc.subject.koPharmaceuticalses_ES
dc.subject.koPolychlorinated biphenylses_ES
dc.subject.koReproductiones_ES


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