Mostrar el registro sencillo del ítem

Chronic treatment with melatonin stimulates dendrite maturation and complexity in adult hippocampal neurogenesis of mice

dc.creatorRamirez-Rodriguez, Gerardo
dc.creatorOrtíz-López, Leonardo
dc.creatorDomínguez-Alonso, Aline
dc.creatorBenítez-King, Gloria A.
dc.creatorKempermann, Gerd
dc.date.accessioned2017-06-29T03:43:12Z
dc.date.available2017-06-29T03:43:12Z
dc.date.issued2011es_ES
dc.identifier2594es_ES
dc.identifier.issn0742-3098es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4443
dc.identifier.urihttps://doi.org/10.1111/j.1600-079X.2010.00802.xes_ES
dc.language.isoenges_ES
dc.publisherAug. 2005- : Oxford : Wileyes_ES
dc.relation50(1) 29-37p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntioxidants-pharmacologyes_ES
dc.subject.meshDendrites-drug effectses_ES
dc.subject.meshDentate Gyrus-cytologyes_ES
dc.subject.meshDentate Gyrus-drug effectses_ES
dc.subject.meshHippocampus-cytologyes_ES
dc.subject.meshHippocampus-drug effectses_ES
dc.subject.meshImmunohistochemistryes_ES
dc.subject.meshMelatonin-pharmacologyes_ES
dc.subject.meshMicees_ES
dc.subject.meshMice, Inbred C57BLes_ES
dc.subject.meshMicrotubule-Associated Proteins-metabolismes_ES
dc.subject.meshMicrotubules-metabolismes_ES
dc.subject.meshNeurogenesis-drug effectses_ES
dc.subject.meshNeurons-cytologyes_ES
dc.subject.meshNeurons-drug effectses_ES
dc.subject.meshNeuropeptides-metabolismes_ES
dc.titleChronic treatment with melatonin stimulates dendrite maturation and complexity in adult hippocampal neurogenesis of micees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratory of Neurogenesis, Department of Neuropharmacology, National Institute of Psychiatry. Mexico DF, Mexicoes_ES
dc.contributor.emailgbernabe@imp.edu.mxes_ES
dc.relation.jnabreviadoJ PINEAL RESes_ES
dc.relation.journalJournal of Pineal Researches_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1600-079Xes_ES
dc.identifier.doi10.1111/j.1600-079X.2010.00802.xes_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaIn the course of adult hippocampal neurogenesis, the postmitotic maturation and survival phase is associated with dendrite maturation. Melatonin modulates the survival of new neurons with relative specificity. During this phase, the new neurons express microtubule-associated protein doublecortin (DCX). Here, we show that the entire population of cells expressing DCX is increased after 14 days of treatment with melatonin. As melatonin also affects microtubule polymerization which is important for neuritogenesis and dendritogenesis, we studied the consequences of chronic melatonin administration on dendrite maturation of DCX-positive cells. Treatment with melatonin increased the number of DCX-positive immature neurons with more complex dendrites. Sholl analysis revealed that melatonin treatment lead to greater complexity of the dendritic tree. In addition, melatonin increased the total volume of the granular cell layer. Besides its survival-promoting effect, melatonin thus also increases dendritic maturation in adult neurogenesis. This might open the opportunity of using melatonin as an adjuvant in attempts to extrinsically stimulate adult hippocampal neurogenesis in neuropsychiatric disease, dementia or cognitive ageing.es_ES
dc.subject.koAdult neurogenesises_ES
dc.subject.koCytoskeletones_ES
dc.subject.koDendriteses_ES
dc.subject.koDoublecortines_ES
dc.subject.koMelatonines_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem