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Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines
dc.creator | Calleja-Castillo, Juan Manuel | |
dc.creator | De La Cruz-Aguilera, Dora Luz | |
dc.creator | Manjarrez, Joaquin | |
dc.creator | Velasco-Velazquez, Marco Antonio | |
dc.creator | Morales-Espinoza, Gabriel | |
dc.creator | Moreno-Aguilar, Julia | |
dc.creator | Hernandez, Maria Eugenia | |
dc.creator | Aguirre-Cruz, Lucinda | |
dc.creator | Pavon, Lenin | |
dc.date.accessioned | 2017-06-29T03:43:10Z | |
dc.date.available | 2017-06-29T03:43:10Z | |
dc.date.issued | 2013 | es_ES |
dc.identifier | 2593 | es_ES |
dc.identifier.issn | 1740-2522 | es_ES |
dc.identifier.uri | es_ES | |
dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/4442 | |
dc.identifier.uri | https://doi.org/10.1155/2013/698634 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Hindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 PMB, New York, NY 10022 USA | es_ES |
dc.relation | 1-10p. | es_ES |
dc.relation | versión del editor | es_ES |
dc.rights | acceso cerrado | es_ES |
dc.subject.mesh | es_ES | |
dc.title | Chronic Deep Brain Stimulation of the Hypothalamic Nucleus in Wistar Rats Alters Circulatory Levels of Corticosterone and Proinflammatory Cytokines | es_ES |
dc.title.alternative | es_ES | |
dc.type | artículo | es_ES |
dc.contributor.affiliation | Natl Inst Neurol & Neurosurg Manuel Velasco Suare, Lab Neuroimmunoendocrinol, Ave Insurgentes Sur 3877, Mexico City 14269, DF, Mexico. | es_ES |
dc.contributor.email | mariluci_guirre@hotmail.com; lkuriaki@imp.edu.mx | es_ES |
dc.relation.jnabreviado | CLIN DEV IMMUNOL | es_ES |
dc.relation.journal | Clinical & developmental immunology | es_ES |
dc.identifier.place | New York | es_ES |
dc.date.published | 2013 | es_ES |
dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
dc.identifier.eissn | 1740-2530 | es_ES |
dc.identifier.doi | 10.1155/2013/698634 | es_ES |
dc.description.month | Sep | es_ES |
dc.description.abstractotrodioma | Deep brain stimulation (DBS) is a therapeutic option for several diseases, but its effects on HPA axis activity and systemic inflammation are unknown. This study aimed to detect circulatory variations of corticosterone and cytokines levels in Wistar rats, after 21 days of DBS-at the ventrolateral part of the ventromedial hypothalamic nucleus (VMHvl), unilateral cervical vagotomy (UCVgX), or UCVgX plus DBS. We included the respective control (C) and sham (S) groups (n = 6 rats per group). DBS treated rats had higher levels of TNF-alpha (120%; P < 0.01) and IFN-gamma (305%; P < 0.001) but lower corticosterone concentration (48%; P < 0.001) than C and S. UCVgX animals showed increased corticosterone levels (154%; P < 0.001) versus C and S. UCVgX plus DBS increased IL-1 beta (402%; P < 0.001), IL-6 (160%; P < 0.001), and corsticosterone (178%; P < 0.001 versus 48%; P < 0.001) compared with the C and S groups. Chronic DBS at VMHvl induced a systemic inflammatory response accompanied by a decrease of HPA axis function. UCVgX rats experienced HPA axis hyperactivity as result of vagus nerve injury; however, DBS was unable to block the HPA axis hyperactivity induced by unilateral cervical vagotomy. Further studies are necessary to explore these findings and their clinical implication. | es_ES |
dc.subject.meshm | es_ES | |
dc.subject.ko | es_ES |
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