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Central nervous system effects and chemical composition of two subspecies of Agastache mexicana; an ethnomedicine of Mexico

dc.creatorEstrada-Reyes, Rosa
dc.creatorLópez-Rubalcava, C.
dc.creatorFerreyra-Cruz, Octavio Alberto
dc.creatorDorantes-Barrón, Ana María
dc.creatorHeinze, G.
dc.creatorMoreno Aguilar, Julia
dc.creatorMartínez-Vázquez, Mariano
dc.date.accessioned2017-06-29T03:42:56Z
dc.date.available2017-06-29T03:42:56Z
dc.date.issued2014es_ES
dc.identifier2587es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4436
dc.identifier.urihttps://doi.org/10.1016/j.jep.2013.12.057es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation153(1) 98-110p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAgastache/chemistryes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Anxiety Agents/isolation and purificationes_ES
dc.subject.meshAnti-Anxiety Agents/pharmacologyes_ES
dc.subject.meshAnti-Anxiety Agents/toxicityes_ES
dc.subject.meshAntidepressive Agents/isolation and purificationes_ES
dc.subject.meshAntidepressive Agents/pharmacologyes_ES
dc.subject.meshAntidepressive Agents/toxicityes_ES
dc.subject.meshChromatography, High Pressure Liquides_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshHypnotics and Sedatives/isolation and purificationes_ES
dc.subject.meshHypnotics and Sedatives/pharmacologyes_ES
dc.subject.meshHypnotics and Sedatives/toxicityes_ES
dc.subject.meshLethal Dose 50es_ES
dc.subject.meshMalees_ES
dc.subject.meshMedicine, Traditional/methodses_ES
dc.subject.meshMexicoes_ES
dc.subject.meshMicees_ES
dc.subject.meshMotor Activity/drug effectses_ES
dc.subject.meshPlant Components, Aeriales_ES
dc.subject.meshPlant Extracts/administration and dosagees_ES
dc.subject.meshPlant Extracts/pharmacologyes_ES
dc.subject.meshPlant Extracts/toxicityes_ES
dc.subject.meshToxicity Tests, Acutees_ES
dc.titleCentral nervous system effects and chemical composition of two subspecies of Agastache mexicana; an ethnomedicine of Mexicoes_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México Xochimilco 101, Sn. Lorenzo Huipulco, México, D.F. 14370, Méxicoes_ES
dc.contributor.emailes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of ethnopharmacologyes_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2013.12.057es_ES
dc.description.monthAbres_ES
dc.description.abstractotrodiomaEthnopharmacological relevance: Agastache mexicana subspecies mexicana (Amm) and xolocotziana (Amx) are used in Mexican traditional medicine to relief cultural affiliation syndromes known as susto or espanto, for nervou condition, and as a sleep aid. Despite its intensive use, neuropharmacological studies are scarce, and the chemical composition of the aqueous extracts has not been described. Aims of the study are: (1) To analyze the chemical composition of aqueous extracts from aerial parts of Amm and Amx. (2) To evaluate the anxiolytic-like, sedative, antidepressant-like effects. (3) Analyze the general toxic effects of different doses. Materials and methods: Anxiolytic-like and sedative effects were measured in the avoidance exploratory behavior, burying behavior and the hole-board tests. The antidepressant-like actions were studied in the forced swimming and tail suspension tests. Finally, general activity and motor coordination disturbances were evaluated in the open field, inverted screen and rota-rod tests. The acute toxicity of Amm and Amx was determined by calculating their LD50 (mean lethal dose). The chemical analyses were performed employing chromatographic, photometric and HPLC–ESI-MS techniques. Results: Low doses of Amm and Amx (0.1s1.0 mg/kg) induced anxiolytic-like actions; while higher doses (over 10 mg/kg) induced sedation and reduced the locomotor activity, exerting a general inhibition in the central nervous system (CNS). Conclusions: Results support the use of Amm and Amx in traditional medicine as tranquilizers and sleep inducers. Additionally, this paper contributes to the knowledge of the chemical composition of the aqueous extracts of these plants.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koToronjil moradoes_ES
dc.subject.koToronjil blancoes_ES
dc.subject.koAgastache mexicana spp.es_ES
dc.subject.koMexicanaes_ES
dc.subject.koAgastache mexicana ssp. xolocotzianaes_ES
dc.subject.koAnxietyes_ES
dc.subject.koCultural affiliation syndromeses_ES


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