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Calcium current in type I hair cells isolated from the semicircular canal crista ampullaris of the rat

dc.creatorAlmanza, Angélica
dc.creatorVega, Rosario
dc.creatorSoto, Enrique
dc.date.accessioned2017-06-29T03:42:43Z
dc.date.available2017-06-29T03:42:43Z
dc.date.issued2003es_ES
dc.identifier2581es_ES
dc.identifier.issn0006-8993es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4430
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2003.09.033es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation994(2) 175-180p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnimals, Newbornes_ES
dc.subject.meshCalcium/metabolismes_ES
dc.subject.meshCalcium Channel Blockers/pharmacologyes_ES
dc.subject.meshCalcium Channels/drug effectses_ES
dc.subject.meshCalcium Channels/physiologyes_ES
dc.subject.meshCells, Culturedes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshDose-Response Relationship, Radiationes_ES
dc.subject.meshElectric Conductivityes_ES
dc.subject.meshElectric Stimulationes_ES
dc.subject.meshHair Cells, Auditory/drug effectses_ES
dc.subject.meshHair Cells, Auditory/physiologyes_ES
dc.subject.meshMembrane Potentials/drug effectses_ES
dc.subject.meshMembrane Potentials/physiologyes_ES
dc.subject.meshNimodipine/pharmacologyes_ES
dc.subject.meshPatch-Clamp Techniques/methodses_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Long-Evanses_ES
dc.subject.meshSemicircular Canals/cytologyes_ES
dc.subject.meshSemicircular Canals/drug effectses_ES
dc.subject.meshSemicircular Canals/physiologyes_ES
dc.titleCalcium current in type I hair cells isolated from the semicircular canal crista ampullaris of the rates_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto de Fisiología, Universidad Autónoma de Puebla, Apartado Postal 406 Puebla, Pue, 72000 Mexicoes_ES
dc.contributor.emailanalman@siu.buap.mxes_ES
dc.relation.jnabreviadoBRAIN RESes_ES
dc.relation.journalBrain researches_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-6240es_ES
dc.identifier.doi10.1016/j.brainres.2003.09.033es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaThe low voltage gain in type I hair cells implies that neurotransmitter release at their afferent synapse should be mediated by low voltage activated calcium channels, or that some peculiar mechanism should be operating in this synapse. With the patch clamp technique, we studied the characteristics of the Ca(2+) current in type I hair cells enzymatically dissociated from rat semicircular canal crista ampullaris. Calcium current in type I hair cells exhibited a slow inactivation (during 2-s depolarizing steps), was sensitive to nimodipine and was blocked by Cd(2+) and Ni(2+). This current was activated at potentials above -60 mV, had a mean half maximal activation of -36 mV, and exhibited no steady-state inactivation at holding potentials between -100 and -60 mV. This data led us to conclude that hair cell Ca(2+) current is most likely of the L type. Thus, other mechanisms participating in neurotransmitter release such as K(+) accumulation in the synaptic cleft, modulation of K(+) currents by nitric oxide, participation of a Na(+) current and possible metabotropic cascades activated by depolarization should be considered.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koCalcium channelses_ES
dc.subject.koDihydropyridinees_ES
dc.subject.koInner eares_ES
dc.subject.koAfferent synapsees_ES
dc.subject.koCalyx synapsees_ES
dc.subject.koTransmitter releasees_ES
dc.subject.koVestibular systemes_ES
dc.creator.ides_ES


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