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Brain thyrotropin-releasing hormone content varies through amygdaloid kindling development according to afterdischarge frequency and propagation

dc.creatorDe Gortari, P.
dc.creatorJoseph-Bravo, P.
dc.creatorMonroy-Ruiz, J.
dc.creatorMartinez, A.
dc.creatorCisneros, M.
dc.creatorFernández Guardiola, A.
dc.date.accessioned2017-06-29T03:42:35Z
dc.date.available2017-06-29T03:42:35Z
dc.date.issued1998es_ES
dc.identifier2577es_ES
dc.identifier.issn0013-9580es_ES
dc.identifier.urihttp://dx.doi.org/10.1111/j.1528-1157.1998.tb01188.xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4426
dc.identifier.urihttps://doi.org/10.1111/j.1528-1157.1998.tb01188.xes_ES
dc.language.isoenges_ES
dc.relation39(8) 897-903p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBrain thyrotropin-releasing hormone content varies through amygdaloid kindling development according to afterdischarge frequency and propagationes_ES
dc.typeartículoes_ES
dc.contributor.affiliationlnstituto de Biotecnología of Universidad Nacional Autónoma de Méxicoes_ES
dc.relation.jnabreviadoEPILEPSIAes_ES
dc.relation.journalEpilepsiaes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published1998es_ES
dc.identifier.eissn1528-1167es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaPurpose: Thyrotropin-releasing hormone (TRH), present in extra hypothalamic brain areas, has been proposed to have neuromodulatory functions and to be susceptible to change by electrical stimulation paradigms. We measured TRH concentrations of several brain areas during kindling development before its establishment and determined whether the changes detected in TRH levels were related to the behavioral stages of kindling, the number of stimulations required to reach these stages and, with the electrophysiological parameters characteristic of this paradigm (amygdaloid afterdischarge (AD) frequency, duration, and propagation). Methods: Male Wistar rats were implanted stereotaxically with indwelling bipolar electrodes in the basolateral nucleus of the amygdala and with two stainless-steel electrodes epidurally in frontal cortex. Amygdaloid kindling was induced by daily electrical stimulation; AD frequency and duration were recorded and analyzed throughout the development of kindling. TRH was extracted from several regions and quantified by radioimmunoassay (RIA). Results: Modifications in TRH concentrations were detected, depending on the region assayed, from stage I1 of kindling. A positive correlation was noted between the levels of TRH and the frequency and propagation of AD, but not with the number of stimulations. The rate of change in TRH concentration in relation to AD frequency or duration was highest in frontal cortex followed by hippocampus and amygdala. Conclusions: A graded response was noted in the increase in TRH concentration dependent on the increase of AD frequency and propagation. The rate of response correlated with the region's epileptogenic susceptibilityes_ES
dc.subject.koKindlinges_ES
dc.subject.koAmygdalaes_ES
dc.subject.kon. accumbenses_ES
dc.subject.koAfterdischargees_ES
dc.subject.koThyrotropinreleasing hormonees_ES


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