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Brain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitution

dc.creatorHerrera-Pérez, José Jaime
dc.creatorFernández-Guasti, Alonso
dc.creatorMartínez-Mota, Lucía
dc.date.accessioned2017-06-29T03:42:34Z
dc.date.available2017-06-29T03:42:34Z
dc.date.issued2013es_ES
dc.identifier2576es_ES
dc.identifier.issn2314-4262es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4425
dc.identifier.urihttps://doi.org/10.1155/2013/201909es_ES
dc.language.isoenges_ES
dc.relation1-8p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBrain SERT Expression of Male Rats Is Reduced by Aging and Increased by Testosterone Restitutiones_ES
dc.typeartículoes_ES
dc.contributor.affiliationFarmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.contributor.emaillucia@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROSCI Jes_ES
dc.relation.journalNeuroscience Journales_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2314-4270es_ES
dc.identifier.doi10.1155/2848es_ES
dc.description.abstractotrodiomaIn preclinical and clinical studies aging has been associated with a deteriorated response to antidepressant treatment.We hypothesize that such impairment is explained by an age-related decrease in brain serotonin transporter (SERT) expression associated with lowtestosterone (T) levels.The objectives of this studywere to establish (1) if brain SERT expression is reduced by aging and (2) if the SERT expression in middle-aged rats is increased by T-restitution. Intact young rats (3–5 months) and gonad-intact middle-aged rats with or without T-restitution were used.The identification of the brain SERT expression was done by immunofluorescence in prefrontal cortex, lateral septum, hippocampus, and raphe nuclei. An age-dependent reduction of SERT expression was observed in all brain regions examined, while T-restitution recovered the SERT expression only in the dorsal raphe of middle-aged rats. This last action seems relevant since dorsal raphe plays an important role in the antidepressant action of selective serotonin reuptake inhibitors. All data suggest that this mechanism accounts for the T-replacement usefulness to improve the response to antidepressants in the aged population.es_ES


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