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Behavioral Characteristics, Associative Learning Capabilities, and Dynamic Association Mapping in an Animal Model of Cerebellar Degeneration

dc.creatorPorras-García, Elena
dc.creatorSánchez-Campusano, Raudel
dc.creatorMartínez-Vargas, David
dc.creatorDomínguez-del-Toro, Eduardo
dc.creatorCendelín, Jan
dc.creatorVožeh, František
dc.creatorDelgado-García, José M.
dc.date.accessioned2017-06-29T03:42:31Z
dc.date.available2017-06-29T03:42:31Z
dc.date.issued2010es_ES
dc.identifier2574es_ES
dc.identifier.issn0022-3077es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4423
dc.identifier.urihttps://doi.org/10.1152/jn.00180.2010es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherBethesda Md : American Physiological Societyes_ES
dc.relation104(1) 346-365p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleBehavioral Characteristics, Associative Learning Capabilities, and Dynamic Association Mapping in an Animal Model of Cerebellar Degenerationes_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationes_ES
dc.contributor.emailjmdelgar@upo.eses_ES
dc.relation.jnabreviadoJ NEUROPHYSIOLes_ES
dc.relation.journalJournal of Neurophysiologyes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1522-1598es_ES
dc.identifier.doi10.1152/jn.00180.2010es_ES
dc.description.monthJules_ES
dc.description.abstractotrodiomaYoung adult heterozygous Lurcher mice constitute an excellent model for studying the role of the cerebellar cortex in motor performance—including the acquisition of new motor abilities—because of the early postnatal degeneration of almost all of their Purkinje and granular cells. Wild-type and Lurcher mice were classically conditioned for eyelid responses using a delay paradigm with or without an electrolytic lesion in the interpositus nucleus. Although the late component of electrically evoked blink reflexes was smaller in amplitude and had a longer latency in Lurcher mice than that in controls, the two groups of animals presented similar acquisition curves for eyeblink conditioning. The lesion of the interpositus nucleus affected both groups of animals equally for the generation of reflex and conditioned eyelid responses. Furthermore, we recorded the multiunitary activity at the red and interpositus nuclei during the same type of associative learning. In both nuclei, the neural firing activity lagged the beginning of the conditioned response (determined by orbicularis oculi muscle response). Although red nucleus neurons and muscle activities presented a clear functional coupling (strong correlation and low asymmetry) across conditioning, the coupling between interpositus neurons and either red nucleus neurons or muscle activities was slightly significant (weak correlation and high asymmetry). Lurcher mice presented a nonlinear coupling (high asymmetry) between red nucleus neurons and muscle activities, with an evident compensatory adjustment in the correlation of firing between interpositus and red nuclei neurons (a coupling with low asymmetry), aimed probably at compensating the absence of cerebellar cortical neurons.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koes_ES


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