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BDNF Met66 modulates the cumulative effect of psychosocial childhood adversities on major depression in adolescents

dc.creatorCruz-Fuentes, Carlos S.
dc.creatorBenjet, Corina
dc.creatorMartínez-Levy, Gabriela A.
dc.creatorPérez-Molina, Amado
dc.creatorBriones-Velasco, Magdalena
dc.creatorSuárez-González, Jesús
dc.date.accessioned2017-06-29T03:42:29Z
dc.date.available2017-06-29T03:42:29Z
dc.date.issued2014es_ES
dc.identifier2573es_ES
dc.identifier.issnes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4422
dc.identifier.urihttps://doi.org/10.1002/brb3.220es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisherHoboken, NJ : John Wiley & Sonses_ES
dc.relation4(2) 290-297p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshBrain-Derived Neurotrophic Factor/geneticses_ES
dc.subject.meshChildes_ES
dc.subject.meshChild Abusees_ES
dc.subject.meshDepressive Disorder, Major/etiologyes_ES
dc.subject.meshDepressive Disorder, Major/geneticses_ES
dc.subject.meshFemalees_ES
dc.subject.meshGene-Environment es_ES
dc.titleBDNF Met66 modulates the cumulative effect of psychosocial childhood adversities on major depression in adolescentses_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationPsychiatric Genetics Department, Clinical Research Branch, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, México City, Méxicoes_ES
dc.contributor.emailcruz@imp.edu.mxes_ES
dc.relation.jnabreviadoBRAIN BEHAVes_ES
dc.relation.journalBrain and Behaviores_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2162-3279es_ES
dc.identifier.doi10.1002/brb3.220es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaBackground The interplay among lifetime adversities and the genetic background has been previously examined on a variety of measures of depression; however, only few studies have focused on major depression disorder (MDD) in adolescence. Methods Using clinical data and DNA samples from mouthwash gathered from an epidemiological study on the prevalence of mental disorders in youths between 12 and 17 years old, we tested the statistical interaction between a set of psychosocial adversities experienced during childhood (CAs) with two common polymorphisms in the brain-derived neurotrophic factor (BDNF) (Val66Met) and SLC6A4 (L-S) genes on the probability of suffering MDD in adolescence. Results Genotype or allele frequencies for both polymorphisms were similar between groups of comparison (MDD N = 246; controls N = 270). The CAs factors: Abuse, neglect, and family dysfunctions; parental maladjustment, parental death, and to have experienced a life-threatening physical illness were predictors of clinical depression in adolescents. Remarkably, the cumulative number of psychosocial adversities was distinctly associated with an increase in the prevalence of depression but only in those Val-Val BDNF individuals; while the possession of at least a copy of the BDNF Met allele (i.e., Met +) was statistically linked with a ‘refractory’ or resilient phenotype to the noticeable influence of CAs. Conclusion Liability or resilience to develop MDD in adolescence is dependent of a complex interplay between particular environmental exposures and a set of plasticity genes including BDNF. A better understanding of these factors is important for developing better prevention and early intervention measures.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koAdolescencees_ES
dc.subject.koBrain-derived neurotrophic factor genees_ES
dc.subject.koChildhood adversitieses_ES
dc.subject.koMajor depressiones_ES
dc.subject.koMexicanes_ES
dc.subject.koSerotonin transporter genees_ES


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