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Association study between the MDR1 gene and clinical characteristics in schizophrenia

dc.creatorTovilla-Zárate, Carlos A.
dc.creatorVargas, Iván
dc.creatorHernández, Sandra
dc.creatorFresán, Ana
dc.creatorAguilar, Alejandro
dc.creatorEscamilla, Raúl
dc.creatorSaracco, Ricardo
dc.creatorPalacios, Jorge
dc.creatorCamarena, Beatriz
dc.date.accessioned2017-06-29T03:41:58Z
dc.date.available2017-06-29T03:41:58Z
dc.date.issued2014es_ES
dc.identifier2558es_ES
dc.identifier.issn1516-4446es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4407
dc.identifier.urihttps://doi.org/10.1590/1516-4446-2013-1270es_ES
dc.language.isoenges_ES
dc.publisherSão Paulo, SP, Brasil : Associação Brasileira de Psiquiatriaes_ES
dc.relation36(3) 227-232p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdolescentes_ES
dc.subject.meshAdultes_ES
dc.subject.meshAnalysis of Variancees_ES
dc.subject.meshFemalees_ES
dc.subject.meshGene Frequencyes_ES
dc.subject.meshGenetic Associationes_ES
dc.subject.meshStudieses_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHumanses_ES
dc.subject.meshMalees_ES
dc.subject.meshMexicoes_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshP-Glycoprotein-Geneticses_ES
dc.subject.meshPolymerase Chain Reactiones_ES
dc.subject.meshPolymorphism, Single Nucleotide-Geneticses_ES
dc.subject.meshSchizophrenia-Geneticses_ES
dc.subject.meshSeverity of Illness Indexes_ES
dc.subject.meshSex Factorses_ES
dc.subject.meshYoung Adultes_ES
dc.titleAssociation study between the MDR1 gene and clinical characteristics in schizophreniaes_ES
dc.typeartículoes_ES
dc.contributor.affiliationUniversidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco, Mexico.es_ES
dc.contributor.emailcamare@imp.edu.mxes_ES
dc.relation.jnabreviadoREV BRAS PSIQUIATRes_ES
dc.relation.journalRevista Brasileira de Psiquiatriaes_ES
dc.identifier.placeBrasiles_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1809-452Xes_ES
dc.identifier.doi10.1590/1516-4446-2013-1270es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaObjective: Schizophrenia is a complex psychiatric disorder, characterized by disturbed patterns of thought and affecting 0.3-2.0% of the world population. Previously, the multidrug resistance 1 (MDR1) gene has been associated with schizophrenia in treatment response studies in psychotic patients. The aim of this study was to determine the association between MDR1 gene polymorphisms and clinical characteristics in patients with schizophrenia. Methods: Positive and negative symptoms of schizophrenia were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and the Scale for the Assessment of Positive Symptoms (SAPS) in 158 Mexican patients with schizophrenia. Analyses of MDR1 gene polymorphisms were performed using TaqMan technology. A multivariate ANOVA was performed with MDR1 polymorphisms and gender as independent variables. Results: Males with the G/G genotype of MDR1 rs2032582 presented significantly higher levels of delusions (p = 0.02). When comparing female vs. male groups, the difference was statistically significant (p = 0.0003). Analyses of the MDR1 gene rs1045642 variant showed no significant differences. Conclusion: Our findings suggest that male carriers of the G allele of variant rs2032582 exhibit greater severity of delusions; however, these results should be taken as preliminary, and replication studies in other populations of different ethnic origins are required to confirm these findings.es_ES
dc.subject.koSchizophreniaes_ES
dc.subject.koMDR1 genees_ES
dc.subject.koPolymorphismes_ES
dc.subject.koMexican populationes_ES
dc.subject.koSANSes_ES
dc.subject.koSAPSes_ES


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