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Anxious and non-anxious major depressive disorder in the World Health Organization World Mental Health Survey

dc.creatorKessler, R.C.
dc.creatorSampson, N.A.
dc.creatorBerglund, P.
dc.creatorGruber, M.J.
dc.creatorAlHamzawi, A.
dc.creatorAndrade, L.
dc.creatorBunting, B.
dc.creatorDemyttenaere, K.
dc.creatorFlorescu, S.
dc.creatorDe Girolamo,  G.
dc.creatorGureje, O.
dc.creatorHe, Y.
dc.creatorHu, C.
dc.creatorHuang, Y.
dc.creatorKaram, E. Kovess-Masfety, V.
dc.creatorLee, S.
dc.creatorFRCPsych
dc.creatorLevinson, D.
dc.creatorMedina Mora, M.E.
dc.creatorMoskalewicz, J.
dc.creatorNakamura, Y.
dc.creatorNavarro-Mateu, F.
dc.creatorOakley Browne, Mark A.
dc.creatorPiazza, S.
dc.creatorPosada-Villa, J.
dc.creatorSlade, T.
dc.creatorTen Have, M.
dc.creatorTorres, Y.
dc.creatorVilagut, G.
dc.creatorXavier, M.
dc.creatorZarkov, Z.
dc.creatorShahly, V.
dc.creatorWilcox, M.A.
dc.date.accessioned2017-06-29T03:41:43Z
dc.date.available2017-06-29T03:41:43Z
dc.date.issued2015es_ES
dc.identifier2548es_ES
dc.identifier.issn2045-7960es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4397
dc.identifier.urihttp://doi.org/10.1017/S2045796015000189es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation24(3) 210-226p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleAnxious and non-anxious major depressive disorder in the World Health Organization World Mental Health Surveyes_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartment of Health Care Policy, Harvard Medical School, Boston, MA, USAes_ES
dc.contributor.emailkessler@hcp.med.harvard.edues_ES
dc.relation.jnabreviadoEPIDEMIOL PSYCHIATR SCIes_ES
dc.relation.journalEpidemiology and psychiatric scienceses_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2015es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2045-7979es_ES
dc.identifier.doi10.1017/S2045796015000189es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaBACKGROUND: To examine cross-national patterns and correlates of lifetime and 12-month comorbid DSM-IV anxiety disorders among people with lifetime and 12-month DSM-IV major depressive disorder (MDD).METHOD:Nationally or regionally representative epidemiological interviews were administered to 74 045 adults in 27 surveys across 24 countries in the WHO World Mental Health (WMH) Surveys. DSM-IV MDD, a wide range of comorbid DSM-IV anxiety disorders, and a number of correlates were assessed with the WHO Composite International Diagnostic Interview (CIDI).RESULTS:45.7% of respondents with lifetime MDD (32.0-46.5% inter-quartile range (IQR) across surveys) had one of more lifetime anxiety disorders. A slightly higher proportion of respondents with 12-month MDD had lifetime anxiety disorders (51.7%, 37.8-54.0% IQR) and only slightly lower proportions of respondents with 12-month MDD had 12-month anxiety disorders (41.6%, 29.9-47.2% IQR). Two-thirds (68%) of respondents with lifetime comorbid anxiety disorders and MDD reported an earlier age-of-onset (AOO) of their first anxiety disorder than their MDD, while 13.5% reported an earlier AOO of MDD and the remaining 18.5% reported the same AOO of both disorders. Women and previously married people had consistently elevated rates of lifetime and 12-month MDD as well as comorbid anxiety disorders. Consistently higher proportions of respondents with 12-month anxious than non-anxious MDD reported severe role impairment (64.4 v. 46.0%; χ 2 1 = 187.0, p < 0.001) and suicide ideation (19.5 v. 8.9%; χ 2 1 = 71.6, p < 0.001). Significantly more respondents with 12-month anxious than non-anxious MDD received treatment for their depression in the 12 months before interview, but this difference was more pronounced in high-income countries (68.8 v. 45.4%; χ 2 1 = 108.8, p < 0.001) than low/middle-income countries (30.3 v. 20.6%; χ 2 1 = 11.7, p < 0.001).CONCLUSIONS:Patterns and correlates of comorbid DSM-IV anxiety disorders among people with DSM-IV MDD are similar across WMH countries. The narrow IQR of the proportion of respondents with temporally prior AOO of anxiety disorders than comorbid MDD (69.6-74.7%) is especially noteworthy. However, the fact that these proportions are not higher among respondents with 12-month than lifetime comorbidity means that temporal priority between lifetime anxiety disorders and MDD is not related to MDD persistence among people with anxious MDD. This, in turn, raises complex questions about the relative importance of temporally primary anxiety disorders as risk markers v. causal risk factors for subsequent MDD onset and persistence, including the possibility that anxiety disorders might primarily be risk markers for MDD onset and causal risk factors for MDD persistencees_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koAnxious depressiones_ES
dc.subject.koComorbidityes_ES
dc.subject.koEpidemiologyes_ES


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