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Anxiolytic-like and sedative actions of Rollinia mucosa: Possible involvement of the GABA/benzodiazepine receptor complex

dc.creatorEstrada-Reyes Rosa
dc.creatorLópez-Rubalcava Carolina
dc.creatorRocha Luisa
dc.creatorHeinze Gerardo
dc.creatorGonzález Esquinca Alma Rosa
dc.creatorMartínez-Vázquez Mariano
dc.date.accessioned2017-06-29T03:41:42Z
dc.date.available2017-06-29T03:41:42Z
dc.date.issued2010es_ES
dc.identifier2547es_ES
dc.identifier.issn1388-0209es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4396
dc.identifier.urihttps://doi.org/10.3109/13880200903046153es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation48(1) 70-75p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshes_ES
dc.titleAnxiolytic-like and sedative actions of Rollinia mucosa: Possible involvement of the GABA/benzodiazepine receptor complexes_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría, Méxicoes_ES
dc.contributor.emailmarvaz@servidor.unam.mxes_ES
dc.relation.jnabreviadoPharmaceutical Biologyes_ES
dc.relation.journalPHARMACEUTICAL BIOLOGYes_ES
dc.identifier.placees_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1744-5116es_ES
dc.identifier.doi10.3109/13880200903046153es_ES
dc.description.monthes_ES
dc.description.abstractotrodiomaThis study evaluated possible CNS effects of a hexane extract of leaves from Rollinia mucosa (Jacq.) Baill. (Annonaceae). This plant extract induced anxiolytic-like actions similar to those induced by diazepam in the avoidance exploratory behavior paradigm. Its significant activity was shown at doses from 1.62 to 6.25 mg/kg. It also enhanced pentobarbital-induced hypnosis time, and at high doses produced motor coordination impairment. The benzodiazepine (BDZ) receptor binding, evaluated by in vitro autoradiography following a single administration of R. mucosa, revealed that this plant extract reduced BDZ binding in the hippocampus (29%), amygdala (26%), and temporal cortex of mice (36%). In conclusion, the present findings support the proposal that R. mucosa may induce central nervous system (CNS) depressant effects, presumably through an interaction with the GABA/benzodiazepine receptor complex.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koBenzodiazepine receptorses_ES
dc.subject.koRollinia mucosa (Jacq.) Baill.es_ES
dc.subject.koSedativees_ES


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