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Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins

dc.creatorGonzález-Trujano, María Eva
dc.creatorPellicer, Francisco
dc.creatorMena, Pedro
dc.creatorMoreno, Diego A.
dc.creatorGarcía-Viguera, Cristina
dc.date.accessioned2017-06-29T03:41:40Z
dc.date.available2017-06-29T03:41:40Z
dc.date.issued2015es_ES
dc.identifier2546es_ES
dc.identifier.issn0963-7486es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4395
dc.identifier.urihttps://doi.org/10.3109/09637486.2015.1024208es_ES
dc.language.isoenges_ES
dc.relation66(4) 395-399p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnalgesics-Pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAnti-Inflammatory agents-Pharmacologyes_ES
dc.subject.meshChromatography, High pressure liquides_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshHydrolyzable Tannins-Pharmacologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshNociceptive Pain-Drug therapyes_ES
dc.subject.meshPlant Extracts-Pharmacologyes_ES
dc.subject.meshPolyphenols-Pharmacologyes_ES
dc.subject.meshPunicaceaees_ES
dc.titleAntinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitanninses_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente, México, D. F., Méxicoes_ES
dc.contributor.emailpedromiguel.menaparreno@unipr.ites_ES
dc.relation.jnabreviadoINT J FOOD SCI NUTRes_ES
dc.relation.journalInternational Journal of Food Sciences and Nutritiones_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2015es_ES
dc.identifier.eissn1465-3478es_ES
dc.identifier.doi10.3109/09637486.2015.1024208es_ES
dc.description.abstractotrodiomaPomegranate (Punica granatum L.) has been used for centuries for the treatment of inflammatory diseases. However, there is a lack of comprehensive information focused on the properties of a certain pomegranate (poly)phenolic profile to cure pain and gastric injury induced by anti-inflammatory drugs. This study investigated the systemic effects of different doses of a HPLC-characterized pomegranate extract on the formalin-induced nociceptive behavior in mice. The effect of the extract against gastric injury caused by non-steroidal anti-inflammatory drugs and ethanol was also assessed. Pomegranate reduced nociception in both phases of the formalin test, suggesting central and peripheral activities to inhibit nociception. Indomethacin-induced gastric injury was not produced in the presence of pomegranate, which also protected against ethanol-induced gastric lesions. The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory propertieses_ES
dc.subject.koAnti-inflammatoryes_ES
dc.subject.koAntinociceptiones_ES
dc.subject.koAnthocyanines_ES
dc.subject.koEllagitannines_ES
dc.subject.koFormalin testes_ES
dc.subject.koGastroprotectiones_ES


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