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Antihyperalgesic activity of Rhodiola rosea in a diabetic rat model

dc.creatorDéciga-Campos, Myrna
dc.creatorGonzález-Trujano, Maria Eva
dc.creatorVentura-Martínez, Rosa
dc.creatorMontiel-Ruiz, Rosa Mariana
dc.creatorÁngeles-López, Guadalupe Esther
dc.creatorBrindis, Fernando
dc.date.accessioned2017-06-29T03:41:39Z
dc.date.available2017-06-29T03:41:39Z
dc.date.issued2016es_ES
dc.identifier2545es_ES
dc.identifier.issn0272-4391es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4394
dc.identifier.urihttps://doi.org/10.1002/ddr.21289es_ES
dc.language.isoenges_ES
dc.relation77(1) 29-36p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshDiabetes Mellitus, Experimental-Complicationses_ES
dc.subject.meshDiabetes Mellitus, Experimental-Drug therapyes_ES
dc.subject.meshDose-Response relationship, druges_ES
dc.subject.meshEthanol-Administration and dosagees_ES
dc.subject.meshEthanol-Therapeutic usees_ES
dc.subject.meshHyperalgesia-Chemically inducedes_ES
dc.subject.meshHyperalgesia-Drug therapyes_ES
dc.subject.meshMalees_ES
dc.subject.meshPain measurementes_ES
dc.subject.meshPlant extracts-Chemistryes_ES
dc.subject.meshRatses_ES
dc.subject.meshRhodiola-Chemistryes_ES
dc.subject.meshStreptozocines_ES
dc.titleAntihyperalgesic activity of Rhodiola rosea in a diabetic rat modeles_ES
dc.typeartículoes_ES
dc.contributor.affiliationSección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina del Instituto Politécnico Nacional (IPN), Plan de San Luis y Díaz Mirón s/n Col. Santo Tomas, Delegación Miguel Hidalgo. C.P. 11340; México D.F (México)es_ES
dc.contributor.emailmyrnadeciga@hotmail.com, mdeciga@ipn.com.mxes_ES
dc.relation.jnabreviadoDRUG DEV RESes_ES
dc.relation.journalDrug Development Researches_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2016es_ES
dc.identifier.doi10.1002/ddr.21289es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaRhodiola rosea L. (Crassulaceae) is used for enhancing physical and mental performance. Recent studies demonstrated that R. rosea had anti-inflammatory activity in animal models, for example, carrageenan- and nystatin-induced edema in rats, possibly by inhibiting phospholipase A2 and cyclooxygenases-1 and -2. In addition, R. rosea had antinociceptive activity in thermal and chemical pain tests as well as mechanical hyperalgesia. The purpose of the present study was to assess the antihyperalgesic effect of an ethanol extract of Rhodiola rosea (R. rosea) in a diabetic rat model. Rats were administered a single dose of streptozotocin (STZ; 50 mg/kg, i.p.) and hyperalgesia was evaluated four weeks later. Formalin-evoked (0.5%) flinching was increased in diabetic rats compared with nondiabetic controls Systemic (1–100 mg/kg, i.p.) and local (0.1–10 mg/paw into the dorsal surface of the right hind paw) administration of R. rosea ethanol extract dose-dependently reduced formalin-induced hyperalgesia in diabetic rats. The antihyperalgesic effect of R. rosea was compared with gabapentin. These results suggest that R. rosea ethanol extract may have potential as a treatment for diabetic hyperalgesiaes_ES
dc.subject.koRhodiola roseaes_ES
dc.subject.koDiabetic painful neuropathyes_ES
dc.subject.koNociceptiones_ES
dc.subject.koHyperalgesiaes_ES


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