Mostrar el registro sencillo del ítem

Anti-epileptogenic effect of high-frequency stimulation in the thalamic reticular nucleus on PTZ-induced seizures

dc.creatorPantoja-Jimenez, C. R.
dc.creatorMagdaleno-Madrigal, V. M.
dc.creatorAlmazan-Alvarado, S.
dc.creatorFernandez-Mas, R.
dc.date.accessioned2017-06-29T03:41:36Z
dc.date.available2017-06-29T03:41:36Z
dc.date.issued2014es_ES
dc.identifier2543es_ES
dc.identifier.issn1935-861Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4392
dc.identifier.urihttps://doi.org/10.1016/j.brs.2014.03.012es_ES
dc.language.isoenges_ES
dc.relation7(4) 587-594pes_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnti-epileptogenic effect of high-frequency stimulation in the thalamic reticular nucleus on PTZ-induced seizureses_ES
dc.typeartículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología del Control y la Regulación, Direccion de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.contributor.emailmaleno@imp.edu.mxes_ES
dc.relation.jnabreviadoBRAIN STIMULes_ES
dc.relation.journalBrain Stimulationes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2014es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.brs.2014.03.012es_ES
dc.description.monthJul-Agoes_ES
dc.description.abstractotrodiomaAnti-epileptogenic effect of high-frequency stimulation in the thalamic reticular nucleus on PTZ-induced seizures BACKGROUND:  Deep brain stimulation, specifically high-frequency stimulation (HFS), is an alternative and promising treatment for intractable epilepsies; however, the optimal targets are still unknown. The thalamic reticular nucleus (TRN) occupies a key position in the modulation of the cortico-thalamic and thalamo-cortical pathways. OBJECTIVE:  We determined the efficacy of HFS in the TRN against tonic-clonic generalized seizures (TCGS) and status epilepticus (SE), which were induced by scheduled pentylenetetrazole (PTZ) injections. METHODS:  Male Wistar rats were stereotactically implanted and assigned to three experimental groups: Control group, which received only PTZ injections; HFS-TRN group, which received HFS in the left TRN prior to PTZ injections; and HFS-Adj group, which received HFS in the left adjacent nuclei prior to PTZ injections. RESULTS:  The HFS-TRN group reported a significant increase in the latency for development of TCGS and SE compared with the HFS-Adj and Control groups (P < 0.009). The number of PTZ-doses required for SE was also significantly increased (P < 0.001). Spectral analysis revealed a significant decrease in the frequency band from 0.5 Hz to 4.5 Hz of the left motor cortex in the HFS-TRN and HFS-Adj groups, compared to the Control group. Conversely, HFS-TRN provoked a significant increase in all frequency bands in the TRN. EEG asynchrony was observed during spike-wave discharges by HFS-TRN. CONCLUSION:  These data indicate that HFS-TRN has an anti-epileptogenic effect and is able to modify seizure synchrony and interrupt abnormal EEG recruitment of thalamo-cortical and, indirectly, cortico-thalamic pathways.es_ES
dc.subject.koThalamic Reticular Nucleuses_ES
dc.subject.koDeep Brain Stimulationes_ES
dc.subject.koSpike-Wave Dischargeses_ES
dc.subject.koNeuromodulationes_ES
dc.subject.koExperimental Epileptic Seizureses_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem