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Antidepressant-like and toxicological effects of a standardized aqueous extract of Chrysactinia mexicana A. Gray (Asteraceae) in mice

dc.creatorCassani, Julia
dc.creatorFerreyra-Cruz, Octavio Alberto
dc.creatorDorantes-Barrón, Ana María
dc.creatorVigueras Villaseñor, Rosa María
dc.creatorArrieta-Baez, Daniel
dc.creatorEstrada-Reyes, Rosa
dc.date.accessioned2017-06-29T03:41:34Z
dc.date.available2017-06-29T03:41:34Z
dc.date.issued2015es_ES
dc.identifier2541es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/4390
dc.identifier.urihttps://doi.org/10.1016/j.jep.2015.05.055es_ES
dc.description.abstractes_ES
dc.language.isoenges_ES
dc.publisheres_ES
dc.relation17 295-306p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive Agents/analysises_ES
dc.subject.meshAntidepressive Agents/pharmacologyes_ES
dc.subject.meshAntidepressive Agents/toxicityes_ES
dc.subject.meshAsteraceae*es_ES
dc.subject.meshBehavior, Animal/drug effectses_ES
dc.subject.meshFlavonoids/analysises_ES
dc.subject.meshFlavonoids/pharmacologyes_ES
dc.subject.meshFlavonoids/toxicityes_ES
dc.subject.meshHindlimb Suspensiones_ES
dc.subject.meshLethal Dose 50es_ES
dc.subject.meshMalees_ES
dc.subject.meshMicees_ES
dc.subject.meshMotor Activity/drug effectses_ES
dc.subject.meshMuscle Strength/drug effectses_ES
dc.subject.meshPhytochemicals/analysises_ES
dc.subject.meshPhytochemicals/pharmacologyes_ES
dc.subject.meshPhytochemicals/toxicityes_ES
dc.subject.meshPlant Components, Aeriales_ES
dc.subject.meshPlant Extracts/analysises_ES
dc.subject.meshPlant Extracts/pharmacologyes_ES
dc.subject.meshPlant Extracts/toxicityes_ES
dc.subject.meshPsychomotor Performance/drug effectses_ES
dc.subject.meshRotarod Performance Testes_ES
dc.subject.meshSwimminges_ES
dc.titleAntidepressant-like and toxicological effects of a standardized aqueous extract of Chrysactinia mexicana A. Gray (Asteraceae) in micees_ES
dc.title.alternativees_ES
dc.typeartículoes_ES
dc.contributor.affiliationDepartamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Unidad Xochimilco, Mexico D.F. 04960, Mexicoes_ES
dc.contributor.emailes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of ethnopharmacologyes_ES
dc.identifier.placeIrlandaes_ES
dc.date.published2015es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2015.05.055es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaEthnopharmacological relevance: C. mexicana A. Gray (Asteraceae) is a native of North America plant. In Mexico's folk medicine it is used for the fever, rheumatism and as a diuretic, antispasmodic, general tonic or adaptogenic herb, and as a stimulant agent. The aim of the study was to examine the antidepressant-like properties of an aqueous extract of C. mexicana (Cm), in order to scientifically describe its potential value in the management of depressive disorders. To evaluate the acute and subacute toxic effects of Cm and effects on hepatic and biochemical functions in mice. Materials and methods: Antidepressant-like effects of Cm were evaluated in the Forced swimming and suspension tail tests (FST and TST), the ambulatory activity was measure in the Open Field Test (OFT), motor coordination was evaluated in the inverted screen and gyratory roller (IST and Rota-rod), the biochemical and histopathological analysis were carried out. Phytochemical studies of organic and aqueous extracts of Cm were thoroughly conducted. Results: Cm produced a significant reduction of the immobility time both FST and in TST, without affect the ambulatory activity of experimental mice. Cm did not produce any damage in the hepatic functions, nor produce any significant change in the morphological tissue of organs examined. Conclusions: Chrysactinia mexicana induces a clear antidepressant-like effect in mice, without affect any basic functions. The consumption of this medicinal plant does not represent risk for health. The chemical analysis showed the flavonoids free and glycosides mainly.es_ES
dc.subject.meshmes_ES
dc.subject.kwes_ES
dc.subject.koChrysactinia Mexicanaes_ES
dc.subject.koDepressiones_ES
dc.subject.koToxicityes_ES
dc.subject.koDamianitaes_ES
dc.subject.koDamiana falsees_ES


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